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N,N'-二异丙基碳二亚胺 → 4-chloro-2-(4-nitrophenylamino)-3H-imidazo-[4,5-c]pyridine
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | N,N'-二异丙基碳二亚胺 | HCID 12734 | — |
| 反应物 | 异硫代氰基4-硝基苯酯 | HCID 75044 | — |
| 反应物 | 2-氯-3,4-二氨基吡啶 | HCID 285736 | — |
| 溶剂 | N,N-二甲基甲酰胺 | HCID 6228 | — |
| 产物 | 4-chloro-2-(4-nitrophenylamino)-3H-imidazo-[4,5-c]pyridine | HCID 178526682 | 82.9% |
反应步骤
3.1 A solution of 0.72 g of 3,4-diamino-2-chloropyridine, 0.9 g of 4-nitrophenyl isothiocyanate and 0.78 ml of N,N-diisopropylcarbodiimide in 30 ml of DMF is stirred at room temperature for 16 hours, then at 500 for 6 hours. The solvent is separated off, and the residue is crystallised from methanol, giving 1.2 g of 4-chloro-2-(4-nitrophenylamino)-3H-imidazo-[4,5-c]pyridine (“6”).
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US07696224B2 |
| 来源数据集 | uspto-grants-2010_04 |
| ORD ID | ord-5af5aee4d7de41bbb82aa03f3bc06196 |
| 来源说明 | uspto-grants-2010_04 |