氯乙酰氯 → N-(2-Cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride

HRID 645769

反应方程式

HRID 645769 反应方程式
C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.[Cl:14]C[C:16](Cl)=[O:17].[C:19]([CH2:21][CH2:22][NH:23][CH3:24])#[N:20].[ClH:25].Cl.COCC(NC(=O)CN1CCNCC1)C>>[ClH:14].[ClH:25].[C:19]([CH2:21][CH2:22][N:23]([CH3:24])[C:16](=[O:17])[CH2:6][N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)#[N:20]

参与物

5

反应物 4

HCID 6577氯乙酰氯HCID 696563-甲胺基丙腈HCID 143452N-BOC-哌嗪HCID 67245894N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide dihydrochloride

产物 1

HCID 67246240N-(2-Cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride

实验过程

N-(2-Cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetylchloride and N-(2-cyanoethyl)-N-methylamine in an analogous manner as described for the preparation of N-(2-methoxy-1-methyl-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride (example 40).

来源与证据

ORD记录
ord-30200bc3bafe4949a91d69ff1e13ca80
来源数据集
uspto-grants-2010_04
专利号
US07705007B2

关联笔记

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