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氯乙酰氯 → N-(2-Cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 氯乙酰氯 | HCID 6577 | — |
| 反应物 | 3-甲胺基丙腈 | HCID 69656 | — |
| 反应物 | N-BOC-哌嗪 | HCID 143452 | — |
| 反应物 | N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide dihydrochloride | HCID 67245894 | — |
| 产物 | N-(2-Cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride | HCID 67246240 | — |
反应步骤
N-(2-Cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide dihydrochloride was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetylchloride and N-(2-cyanoethyl)-N-methylamine in an analogous manner as described for the preparation of N-(2-methoxy-1-methyl-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride (example 40).
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US07705007B2 |
| 来源数据集 | uspto-grants-2010_04 |
| ORD ID | ord-30200bc3bafe4949a91d69ff1e13ca80 |
| 来源说明 | uspto-grants-2010_04 |