二甲基对苯二胺二盐酸 → 5-苯基-2-糠酸

HRID 659114

反应方程式

HRID 659114 反应方程式
[C:1]1([C:7]2[O:11][C:10]([CH:12]=[O:13])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:14].[Na+]>[N+]([O-])([O-])=O.[Ag+]>[C:1]1([C:7]2[O:11][C:10]([C:12]([OH:14])=[O:13])=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参与物

4

反应物 2

HCID 14798二甲基对苯二胺二盐酸2 次HCID 27694205-苯基-2-糠醛

产物 1

HCID 7362555-苯基-2-糠酸

试剂、催化剂与溶剂 1

HCID 24470硝酸银催化剂

反应条件

温度
60 °C

实验过程

To 5-phenyl-2-furaldehyde (35) (690 mg, 4.01 mmol) was added solid NaOH (176 mg, 4.40 mmol) then 10% NaOH solution (6.2 mL). Silver nitrate (680 mg, 4.00 mmol) was added and the reaction mixture heated to 60° C. for 4.5 hours then cooled to ambient temperature. The reaction mixture was then filtered and washed with water. The filtrate was acidified to pH 2 using 2N HCl and the precipitated product filtered and dried to give the title compound.

后处理

  1. temperaturethen cooled to ambient temperature
  2. filtrationThe reaction mixture was then filtered
  3. washwashed with water
  4. filtrationthe precipitated product filtered
  5. customdried

来源与证据

ORD记录
ord-fe5a9621d48b45708e5f897cbdb23907
来源数据集
uspto-grants-2011_12
专利号
US08080567B2

关联笔记

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