反式-2-己烯酸 → 3-Sulfohexanoic acid

HRID 66432

反应方程式

HRID 66432 反应方程式
[C:1]([OH:8])(=[O:7])[CH:2]=[CH:3][CH2:4][CH2:5][CH3:6].[OH-].[Na+].[S:11](=[O:14])([OH:13])[O-:12].[Na+].S(=O)(O)[O-]>>[S:11]([CH:3]([CH2:4][CH2:5][CH3:6])[CH2:2][C:1]([OH:8])=[O:7])([OH:14])(=[O:13])=[O:12]

参与物

5

反应物 4

HCID 14486反式-2-己烯酸HCID 14798二甲基对苯二胺二盐酸HCID 104748酸式亚硫酸盐HCID 23665763亚硫酸氢钠

产物 1

HCID 213296223-Sulfohexanoic acid

实验过程

114 g. of 2-hexenoic acid is neutralized with aqueous sodium hydroxide and reacted with 204 g. of a 50% wt. aqueous solution of sodium bisulfite at 25° C. Complete addition of bisulfite to the double bond requires several hours. The product is concentrated to approximately 50% wt. solids and then treated with a strong acid ion exchange resin to obtain an aqueous solution of 3-sulfohexanoic acid. This is dried by vacuum stripping and converted into 3-propyl-1,2-oxathiolane-5-one-2,2-dioixde with refluxing thionyl chloride at 80° C. for 3 hours. Equivalent weight is 93.

后处理

  1. customreacted with 204 g
  2. customat 25° C
  3. waitrequires several hours
  4. concentrationThe product is concentrated to approximately 50% wt. solids
  5. additiontreated with a strong acid ion exchange resin

来源与证据

ORD记录
ord-e1f5c27a7f8c44479d059796dfe483c5
来源数据集
uspto-grants-1978_12
专利号
US04131736

关联笔记

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