硫代异氰酸苯酯 → N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea

HRID 66562

反应方程式

HRID 66562 反应方程式
C(N(CC)CC)C.Br.[CH3:9][N:10]1[CH2:14][CH2:13][N:12]([CH3:15])[C:11]1=[NH:16].[C:17]1([N:23]=[C:24]=[S:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(Cl)(Cl)Cl>[CH3:9][N:10]1[CH2:14][CH2:13][N:12]([CH3:15])[C:11]1=[N:16][C:24]([NH:23][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[S:25]

参与物

5

反应物 3

HCID 7673硫代异氰酸苯酯HCID 8471三乙胺HCID 134927221,3-Dimethyl-2-imino-imidazolidine hydrobromide

产物 1

HCID 20530303N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea

试剂、催化剂与溶剂 1

HCID 6212三氯甲烷溶剂2 次

实验过程

30.4 g (0.3 mol) of triethylamine are added to a suspension of 58.2 g (0.3 mol) of 1,3-dimethyl-2-imino-imidazolidine hydrobromide in 470 ml of chloroform, at 5°, with stirring. A solution of 40.6 g (0.3 mol) of phenyl isothiocyanate in 235 ml of chloroform is then added dropwise and the reaction mixture is refluxed for 15 hours. After cooling, it is washed with water, dried over sodium sulfate and evaporated in vacuo. Crude N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea is obtained and after recrystallisation from ethanol this melts at 195°-196°.

后处理

  1. temperaturethe reaction mixture is refluxed for 15 hours
  2. temperatureAfter cooling
  3. washit is washed with water
  4. dry with materialdried over sodium sulfate
  5. customevaporated in vacuo

来源与证据

ORD记录
ord-3610284790264e4e93319b0dd2f35d2c
来源数据集
uspto-grants-1982_08
专利号
US04342764

关联笔记

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