乙炔 → 1-Bromo-trans-1-octen-3-one

HRID 67008

反应方程式

HRID 67008 反应方程式
[Br-].[Al+3].[Br-].[Br-].[Br:5][CH2:6][CH2:7]Br.C#C.[C:11](Br)(=[O:17])[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]>[Cl-].[Na+].O>[Br:5]/[CH:6]=[CH:7]/[C:11](=[O:17])[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

参与物

6

反应物 4

HCID 6326乙炔2 次HCID 78391,2-二溴乙烷HCID 166749溴化羟铝HCID 13226800Hexanoyl bromide

产物 1

HCID 117903381-Bromo-trans-1-octen-3-one

试剂、催化剂与溶剂 1

HCID 57417360Sodium chloride; water溶剂

实验过程

A mixture of 300 g. of aluminum bromide and 250 ml. of 1,2-dibromoethane, cooled in an ice bath and protected from moisture, is saturated with acetylene. To the mixture is added with ice cooling 150 g. of hexanoyl bromide (Example 991) over a period of 20 minutes and the resulting mixture is treated with acetylene until gas uptake ceases. The reaction mixture is poured onto 500 ml. of saturated brine and 500 g. of ice. The resulting mixture is extracted twice with 500 ml. of ether. The combined organic extracts are washed twice with 500 ml. of saturated brine and dried with anhydrous sodium sulfate. To the organic phase is added 5 g. of hydroquinone and the solvent is evaporated in vacuo to yield the crude 1-bromo-trans-1-octen-3-one.

后处理

  1. additionA mixture of 300 g
  2. additionThe reaction mixture is poured onto 500 ml
  3. extractionThe resulting mixture is extracted twice with 500 ml
  4. washThe combined organic extracts are washed twice with 500 ml
  5. dry with materialof saturated brine and dried with anhydrous sodium sulfate
  6. additionTo the organic phase is added 5 g
  7. customof hydroquinone and the solvent is evaporated in vacuo

来源与证据

ORD记录
ord-3570da56e8dc4f0faa4be69de5640b85
来源数据集
uspto-grants-1982_08
专利号
US04343949

关联笔记

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