碘 → 6-碘-3,4-二氢-1H-2-喹啉酮

HRID 6812

反应方程式

HRID 6812 反应方程式
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]1=[O:11].[I:12]I>C(O)C.S([O-])([O-])(=O)=O.[Ag+].[Ag+]>[I:12][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[NH:1][C:2](=[O:11])[CH2:3][CH2:4]2

参与物

5

反应物 2

HCID 807碘HCID 647963,4-二氢-2(1H)-喹啉酮

产物 1

HCID 220189516-碘-3,4-二氢-1H-2-喹啉酮

试剂、催化剂与溶剂 2

HCID 159865硫酸银催化剂HCID 702乙醇溶剂2 次

实验过程

3,4-Dihydroquinolin-2(1H)-one (7.5 g; 51 mmol) and silver (I) sulfate (17.5 g; 56.1 mmol) were suspended in ethanol (250 mL). A solution of iodine in ethanol (250 mL) was added slowly to the reaction over 1 hour. After 6 hours, the reaction was filtered through CELITE diatomaceous earth and washed copiously with methanol. The volatiles were removed under vacuum and the crude residue was triturated with ether. The solids were collected on a fritted funnel and dried under vacuum. This provided the title compound.

后处理

  1. filtrationthe reaction was filtered through CELITE diatomaceous earth
  2. washwashed copiously with methanol
  3. customThe volatiles were removed under vacuum
  4. customthe crude residue was triturated with ether
  5. customThe solids were collected on a fritted funnel
  6. customdried under vacuum

来源与证据

ORD记录
ord-d57d16896f9f4187ad5a58a2a543f654
来源数据集
uspto-grants-2006_08
专利号
US07084156B2

关联笔记

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