4-(5-Methyl-1H-1,2,4-triazol-1-yl)benzoic acid → N-Cyclopropyl-N-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-4-(5-methyl-[1,2,4]triazol-1-yl)-benzamide
反应方程式
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[N:16]=[CH:15][C:14]([CH2:17][CH3:18])=[CH:13][N:12]=3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[CH3:19][C:20]1[N:24]([C:25]2[CH:33]=[CH:32][C:28]([C:29](O)=[O:30])=[CH:27][CH:26]=2)[N:23]=[CH:22][N:21]=1>>[CH:1]1([N:4]([CH:5]2[CH2:10][CH2:9][N:8]([C:11]3[N:12]=[CH:13][C:14]([CH2:17][CH3:18])=[CH:15][N:16]=3)[CH2:7][CH2:6]2)[C:29](=[O:30])[C:28]2[CH:27]=[CH:26][C:25]([N:24]3[C:20]([CH3:19])=[N:21][CH:22]=[N:23]3)=[CH:33][CH:32]=2)[CH2:2][CH2:3]1参与物
3
实验过程
The title compound is prepared from cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-piperidin-4-yl]-amine and 4-(5-methyl-[1,2,4]triazol-1-yl)-benzoic acid following a procedure analogous to that described in Example 90. LC (method 19): tR=3.77 min; Mass spectrum (ESI+): m/z=432 [M+H]+.
来源与证据
- ORD记录
- ord-97449188603e497ebe13f2059fdc9468
- 来源数据集
- uspto-grants-2014_09