2-呋喃甲胺 → 2-chloro-5-fluoro-N4-(furfuryl)-4-pyrimidineamine

HRID 71283

反应方程式

HRID 71283 反应方程式
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]3OCC[O:18][C:11]=3C=2)[C:5]([F:19])=[CH:4][N:3]=1.ClC1N=C(Cl)C(F)=CN=1.C(N)C1OC=CC=1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:14]2[O:18][CH:11]=[CH:12][CH:13]=2)[C:5]([F:19])=[CH:4][N:3]=1

参与物

4

反应物 3

HCID 34382-呋喃甲胺HCID 2507052,4-二氯-5-氟嘧啶HCID 220603622-chloro-5-fluoro-N-(3,4-ethylenedioxyphenyl)-4-pyrimidineamine

产物 1

HCID 220607372-chloro-5-fluoro-N4-(furfuryl)-4-pyrimidineamine

实验过程

In a manner similar to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine and furfurylamine were reacted to yield 2-chloro-5-fluoro-N4-(furfuryl)-4-pyrimidineamine. 1H NMR (CDCl3): δ 7.91 (d, 1H, J=1.8 Hz), 7.39 (d, 1H, J=1.2 Hz), 6.35 (m, 2H), 5.50 (bs, 1H), 4.69 (d, 2H, J=5.1 Hz); 19F NMR (CDCl3): −45163; LCMS: ret. time: 24.52 min.; purity: 97%; MS (m/e): 228 (M+).

后处理

  1. customwere reacted

来源与证据

ORD记录
ord-4570eb3d4126420e8e82c05a5c861fd6
来源数据集
uspto-grants-2014_09
专利号
US08822685B2

关联笔记

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