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盐酸 → (rac)-2-(4-(4-(Trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetic acid hydrochloride

HRID 714107
笔记
打印预览

反应方程式

HRID 714107 反应方程式
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]3[CH2:17][CH2:16][CH:15]([O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[C:11]=3[CH:12]=[N:13][CH:14]=2)=[CH:5][CH:4]=1.[ClH:29].O1CCOCC1>C(Cl)Cl>[ClH:29].[F:27][C:2]([F:1])([F:28])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:10]3[CH2:17][CH2:16][CH:15]([O:18][CH2:19][C:20]([OH:22])=[O:21])[C:11]=3[CH:12]=[N:13][CH:14]=2)=[CH:7][CH:8]=1
参与物实验过程后处理来源与证据反应笔记

参与物

5

反应物 3

HCID 313盐酸HCID 312751,4-二氧六环HCID 71811491(rac)-tert-Butyl 2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetate

产物 1

HCID 89846289(rac)-2-(4-(4-(Trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetic acid hydrochloride收率 99%

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

To a cooled (0° C.) solution of (rac)-tert-butyl 2-(4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yloxy)acetate (example 97) (235 mg, 0.597 mmol) in CH2Cl2 (2 mL) was added 4M HCl in dioxane (1.49 mL, 5.97 mmol) and the reaction mixture was stirred at room temperature for 16 h. The mixture was evaporated to dryness to give the title compound (221 mg, 99%) as a grey solid. MS: 338.5 (M+H+).

后处理

  1. customThe mixture was evaporated to dryness

来源与证据

ORD记录
ord-4572692cf41c443a9b94326ca38bf257
来源数据集
uspto-grants-2015_11
DOI
10.6084/m9.figshare.5104873.v1
专利号
US09187429B2

反应笔记

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本页导航参与物实验过程后处理来源与证据反应笔记