哌嗪 → Piperazine, 1,4-bis[(4,5,6-trimethoxy-1H-indol-2-yl)carbonyl]-

反应方程式

[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=[C:8]2[C:4]=1[CH:5]=[C:6]([C:16]([OH:18])=O)[NH:7]2.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=[C:8]2[C:4]=1[CH:5]=[C:6]([C:16]([N:19]1[CH2:24][CH2:23][N:22]([C:16]([C:6]3[NH:7][C:8]4[C:4]([CH:5]=3)=[C:3]([O:2][CH3:1])[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=4)=[O:18])[CH2:21][CH2:20]1)=[O:18])[NH:7]2

参与物

反应物 2

HCID 4837哌嗪

HCID 9075694,5,6-TRIMETHOXY-1H-INDOLE-2-CARBOXYLIC ACID

产物 1

HCID 21891563Piperazine, 1,4-bis[(4,5,6-trimethoxy-1H-indol-2-yl)carbonyl]-

实验过程

4,5,6-Trimethoxyindole-2-carboxylic acid (290 mg) and piperazine (50 mg) were reacted in the same manner as in Preparation Example 37 to obtain the title compound.

来源与证据

ORD记录: ord-3e928eac669a40f4b53971b200ee488a
来源数据集: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07135473B2

反应笔记

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