氯甲酸丙酯 → (R)-3-Propoxycarbonylamino-pyrrolidine-1-carboxylic acid adamantan-2-yl ester

HRID 72130

反应方程式

Cl.[NH2:2][C@@H:3]1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH:11]2[CH:18]3[CH2:19][CH:14]4[CH2:15][CH:16]([CH2:20][CH:12]2[CH2:13]4)[CH2:17]3)=[O:9])[CH2:4]1.Cl[C:22]([O:24][CH2:25][CH2:26][CH3:27])=[O:23]>>[CH2:25]([O:24][C:22]([NH:2][C@@H:3]1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH:11]2[CH:12]3[CH2:13][CH:14]4[CH2:15][CH:16]([CH2:17][CH:18]2[CH2:19]4)[CH2:20]3)=[O:9])[CH2:4]1)=[O:23])[CH2:26][CH3:27]

参与物

反应物 2

HCID 7998氯甲酸丙酯

HCID 67155574(R)-2-adamantyl 3-aminopyrrolidine-1-carboxylate HCl salt

产物 1

HCID 44473378(R)-3-Propoxycarbonylamino-pyrrolidine-1-carboxylic acid adamantan-2-yl ester

实验过程

The title compound was prepared from (R)-2-adamantyl 3-aminopyrrolidine-1-carboxylate HCl salt and propyl chloroformate following a procedure analogous to that described in Example 3 Step 2. LC-MS Method 1 tR=2.00 min, m/z=351; 1H NMR (CDCl3) 0.97 (t, 3H), 1.50-2.05 (16H), 2.19 (m, 1H), 2.42 (1H), 3.29 (dd, 1H), 3.50 (m, 2H), 3.70 (m, 1H), 4.04 (m, 2H), 4.28 (1H), 4.78 (1H), 4.83 (s, 1H)

来源与证据

ORD记录: ord-6148b0cdd1d74a4fa8e81cf13cf32244
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08828985B2

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