乙醇 → 2-Amino-3-(5-chlorobenzotriazol-1-yl)-2-methylpropionitrile

HRID 7217

反应方程式

HRID 7217 反应方程式
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]2[N:6]([CH2:9]C(=O)C)[N:7]=[N:8][C:4]=2[CH:3]=1.[C-:15]#[N:16].[Na+].[Cl-].[NH4+:19].[CH2:20](O)[CH3:21]>N>[NH2:19][C:20]([CH3:21])([CH2:9][N:6]1[C:5]2[CH:13]=[CH:14][C:2]([Cl:1])=[CH:3][C:4]=2[N:8]=[N:7]1)[C:15]#[N:16]

参与物

6

反应物 4

HCID 702乙醇HCID 8929氰化钠HCID 25517氯化铵HCID 220202531-(5-Chlorobenzotriazol-1-yl)-propan-2-one

产物 1

HCID 220202682-Amino-3-(5-chlorobenzotriazol-1-yl)-2-methylpropionitrile

试剂、催化剂与溶剂 1

HCID 222氨溶剂

实验过程

240 mg of 1-(5-chlorobenzotriazol-1-yl)-propan-2-one are dissolved in 4 ml of a 2-molar solution of ammonia in ethanol, then 64 mg of sodium cyanide and 91 mg of ammonium chloride are added and the mixture is stirred over night at room temperature. The reaction mixture is subsequently concentrated by evaporation in a vacuum, dissolved again in ethyl acetate, and washed with water and saturated sodium chloride solution. The organic phase is separated, dried with magnesium sulphate and concentrated by evaporation. 2-amino-3-(5-chlorobenzotriazol-1-yl)-2-methylpropionitrile is thus obtained.

后处理

  1. concentrationThe reaction mixture is subsequently concentrated by evaporation in a vacuum
  2. dissolutiondissolved again in ethyl acetate
  3. washwashed with water and saturated sodium chloride solution
  4. customThe organic phase is separated
  5. dry with materialdried with magnesium sulphate
  6. concentrationconcentrated by evaporation

来源与证据

ORD记录
ord-7ed350118fc746a58b79ffe1365ea045
来源数据集
uspto-grants-2006_08
专利号
US07084280B2

关联笔记

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