丙酮酸 → 2-(2,3,4-Trifluoroanilino)propionic acid

HRID 8441

反应方程式

HRID 8441 反应方程式
[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:11]([OH:16])(=[O:15])[C:12]([CH3:14])=O.[H][H]>CC(O)C.[Pd]>[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH:4][CH:12]([CH3:14])[C:11]([OH:16])=[O:15]

参与物

6

反应物 3

HCID 1060丙酮酸HCID 774682,3,4-三氟苯胺HCID 178418361HCID 178418361，化合物

产物 1

HCID 220158662-(2,3,4-Trifluoroanilino)propionic acid收率 91.4%

试剂、催化剂与溶剂 2

HCID 23938钯催化剂HCID 3776异丙醇溶剂

实验过程

2,3,4-Trifluoroaniline (4.18 g) and pyruvic acid (2.75 g) were dissolved in IPA (40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under atmospheric pressure in a hydrogen atmosphere for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (5.69 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

后处理

  1. filtrationAfter filtering off Pd—C
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

来源与证据

ORD记录
ord-fb9e8a6076c244cb9ed9b7dc84a1a78e
来源数据集
uspto-grants-2006_08
专利号
US07087778B2

关联笔记

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