3-氨基喹啉 → 1-(5-Cyano-3-fluoro-6-(quinolin-3-ylamino)pyridin-2-ylamino)cyclopentanecarboxamide

HRID 84921

反应方程式

HRID 84921 反应方程式
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2([C:14]([NH2:16])=[O:15])[CH2:13][CH2:12][CH2:11][CH2:10]2)[C:5]([F:17])=[CH:4][C:3]=1[C:18]#[N:19].[NH2:20][C:21]1[CH:22]=[N:23][C:24]2[C:29]([CH:30]=1)=[CH:28][CH:27]=[CH:26][CH:25]=2.O.O.O.[O-]C1C=CC=CC=1.[Na+].CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[C:18]([C:3]1[CH:4]=[C:5]([F:17])[C:6]([NH:8][C:9]2([C:14]([NH2:16])=[O:15])[CH2:13][CH2:12][CH2:11][CH2:10]2)=[N:7][C:2]=1[NH:20][C:21]1[CH:22]=[N:23][C:24]2[C:29]([CH:30]=1)=[CH:28][CH:27]=[CH:26][CH:25]=2)#[N:19]

参与物

7

反应物 4

HCID 113753-氨基喹啉HCID 6360444,5-双二苯基膦-9,9-二甲基氧杂蒽HCID 23681143苯酚钠HCID 866661671-(6-Chloro-5-cyano-3-fluoropyridin-2-ylamino)cyclopentanecarboxamide

产物 1

HCID 675097811-(5-Cyano-3-fluoro-6-(quinolin-3-ylamino)pyridin-2-ylamino)cyclopentanecarboxamide

试剂、催化剂与溶剂 2

HCID 9811564三(二亚苄基丙酮)二钯催化剂HCID 312751,4-二氧六环溶剂

实验过程

A mixture of 1-(6-chloro-5-cyano-3-fluoropyridin-2-ylamino)cyclopentanecarboxamide (90 mg, 0.318 mmol), 3-aminoquinoline (58 mg, 0.402 mmol), sodium phenoxide trihydrate (85 mg, 0.500 mmol), xantphos (30 mg, 0.051 mmol) and Pd2 dba3 (20 mg, 0.021 mmol) in dioxane (2 mL) was degassed with Ar, then was stirred at 110 C for 4 h. Water and EtOAc were added. The organic phase was washed with aq. 1N NaOH, dried over Na2SO4, concentrated in vacuo to give crude 1-(5-cyano-3-fluoro-6-(quinolin-3-ylamino)pyridin-2-ylamino)cyclopentanecarboxamide.

后处理

  1. customwas degassed with Ar
  2. additionWater and EtOAc were added
  3. washThe organic phase was washed with aq. 1N NaOH
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated in vacuo

来源与证据

ORD记录
ord-32c07895909e4870bbc7b369a156f02c
来源数据集
uspto-grants-2014_09
专利号
US08846928B2

关联笔记

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