乙醇 → 9-((5-Hydroxypentyl)aminomethyl)anthracene

HRID 849385笔记

反应方程式

HRID 849385 反应方程式
[C:1]1(C=O)[C:14]2[C:5](=[CH:6][C:7]3[C:12]([CH:13]=2)=[CH:11][CH:10]=[CH:9][CH:8]=3)[CH:4]=[CH:3][CH:2]=1.[NH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][OH:23].[BH4-].[Na+].[CH2:26](O)C>>[OH:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][NH:17][CH2:26][C:6]1[C:5]2[C:14]([CH:13]=[C:12]3[C:7]=1[CH:8]=[CH:9][CH:10]=[CH:11]3)=[CH:1][CH:2]=[CH:3][CH:4]=2

参与物

5

反应物 4

HCID 702乙醇HCID 35864AnthracenecarboxaldehydeHCID 756345-氨基-1-戊醇HCID 4311764硼氢化钠

产物 1

HCID 108809079-((5-Hydroxypentyl)aminomethyl)anthracene收率 89.2%

实验过程

A solution of anthraldehyde (9.595 g, 0.0465 mol) and 5-amino-1-pentanol (15.00 g, 0.116 mol) dissolved in 500 mL ethanol at 0° C. was stirred for 3 h. After warming to room temperature the solvent was removed under reduced pressure, and 150 mL of ethanol containing NaBH4 (4.65 g, 0.1229 mol) was added slowly with stirring. The resulting mixture was allowed to stir overnight. The ethanol was removed under reduced pressure and to the brown oil/solid mixture was added 150 mL diethyl ether. Water was added dropwise to this solution until the evolution of hydrogen ceased, followed by the addition of 500 mL water. The ether phase was isolated, washed with 2×50 mL water, dried over sodium sulfate and filtered on a sintered-glass frit. Removal of the solvent afforded 12.17 g (89.2% yield) of 5 as a golden solid; 1H NMR (300.13 MHz, CD3CN) δ 1.51 (m, 6H), 2.81 (t, 2H), 3.49 (t, 2H), 4.68 (s, 2H), 7.52 (m, 4H), 8.05 (d, 2H), 8.44 (m, 3H); 13C-{1H} NMR (75.4 MHz, CDCl3) δ 133.1, 132.0, 131.7, 130.4, 128.6, 127.4, 126.2, 125.1, 62.9, 51.1, 45.8, 33.5, 30.3, 24.8.

后处理

  1. customwas removed under reduced pressure, and 150 mL of ethanol
  2. additionwas added slowly
  3. stirringwith stirring
  4. stirringto stir overnight
  5. customThe ethanol was removed under reduced pressure and to the brown oil/solid mixture
  6. additionwas added 150 mL diethyl ether
  7. additionWater was added dropwise to this solution until the evolution of hydrogen
  8. additionfollowed by the addition of 500 mL water
  9. customThe ether phase was isolated
  10. washwashed with 2×50 mL water
  11. dry with materialdried over sodium sulfate
  12. filtrationfiltered on a sintered-glass frit
  13. customRemoval of the solvent

来源与证据

ORD记录
ord-4015b5ab4b4c49f3996f28cb11096ecf
来源数据集
uspto-grants-2000_01
专利号
US06011984

反应笔记

加载中…