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乙醇 → (+-)-Ethyl-4-(hydroxymethyl)-2-oxazolidinone
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 乙醇 | HCID 702 | — |
| 反应物 | 碳酸二乙酯 | HCID 7766 | — |
| 反应物 | 2-氨基-2-乙基-1,3-丙二醇 | HCID 8282 | — |
| 催化剂 | 甲醇钠 | HCID 10942334 | — |
| 产物 | (+-)-Ethyl-4-(hydroxymethyl)-2-oxazolidinone | HCID 19694098 | — |
反应步骤
Sodium methoxide (2.2 g, Aldrich) was added to a solution of 2-amino-2-ethyl-1,3-propanediol (100.0 g, Aldrich) and diethyl carbonate (169.0 g, Aldrich) This solution was refluxed in a Dean Stark apparatus until no more EtOH was collected. The reaction mixture was cooled, added acetone (200 ml) and allowed to stand overnite at room temperature. The resulting suspension was filtered to give 81.0 g of the desired product as a beige solid. 1H NMR consistent with the proposed structure.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US05723458 |
| 来源数据集 | uspto-grants-1998_03 |
| ORD ID | ord-70a686d8594848a0be625406e5a5cefa |
| 来源说明 | uspto-grants-1998_03 |