乙醇 → (+-)-Ethyl-4-(hydroxymethyl)-2-oxazolidinone

HRID 852

反应方程式

HRID 852 反应方程式
[NH2:1][C:2](CC)([CH2:5][OH:6])[CH2:3][OH:4].[C:9](=O)(OCC)[O:10]CC.[CH3:17][CH2:18]O>C[O-].[Na+]>[CH2:17]([N:1]1[CH:2]([CH2:3][OH:4])[CH2:5][O:6][C:9]1=[O:10])[CH3:18]

参与物

5

反应物 3

HCID 702乙醇HCID 7766碳酸二乙酯HCID 82822-氨基-2-乙基-1,3-丙二醇

产物 1

HCID 19694098(+-)-Ethyl-4-(hydroxymethyl)-2-oxazolidinone

试剂、催化剂与溶剂 1

HCID 10942334甲醇钠催化剂

实验过程

Sodium methoxide (2.2 g, Aldrich) was added to a solution of 2-amino-2-ethyl-1,3-propanediol (100.0 g, Aldrich) and diethyl carbonate (169.0 g, Aldrich) This solution was refluxed in a Dean Stark apparatus until no more EtOH was collected. The reaction mixture was cooled, added acetone (200 ml) and allowed to stand overnite at room temperature. The resulting suspension was filtered to give 81.0 g of the desired product as a beige solid. 1H NMR consistent with the proposed structure.

后处理

  1. customwas collected
  2. temperatureThe reaction mixture was cooled
  3. additionadded acetone (200 ml)
  4. customto stand overnite at room temperature
  5. filtrationThe resulting suspension was filtered

来源与证据

ORD记录
ord-70a686d8594848a0be625406e5a5cefa
来源数据集
uspto-grants-1998_03
专利号
US05723458

关联笔记

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