Halite (NaCl) → 6-(3'-Aminobiphenyl-4-yl)methoxy-2-[2-(N,N-dimethylamino)ethyl]tetralin hydrochloride

HRID 854040

反应方程式

HRID 854040 反应方程式
[NH2:1][C:2]1[CH:3]=[C:4](OB(O)O)[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[Na+].[Na+].Br[C:19]1[CH:41]=[CH:40][C:22]([CH2:23][O:24][C:25]2[CH:26]=[C:27]3[C:32](=[CH:33][CH:34]=2)[CH2:31][CH:30]([CH2:35][CH2:36][N:37]([CH3:39])[CH3:38])[CH2:29][CH2:28]3)=[CH:21][CH:20]=1.[Cl-:42].[Na+]>[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(C)C=CC=CC=1.C(O)C>[ClH:42].[NH2:1][C:2]1[CH:7]=[C:6]([C:19]2[CH:41]=[CH:40][C:22]([CH2:23][O:24][C:25]3[CH:26]=[C:27]4[C:32](=[CH:33][CH:34]=3)[CH2:31][CH:30]([CH2:35][CH2:36][N:37]([CH3:39])[CH3:38])[CH2:29][CH2:28]4)=[CH:21][CH:20]=2)[CH:5]=[CH:4][CH:3]=1

参与物

8

反应物 4

HCID 5234Halite (NaCl)HCID 10340Carbonic acid sodium salt (1:2)HCID 183614846-(4-bromobenzyl)oxy-2-[2-(N,N-dimethylamino)ethyl]tetralinHCID 218958363-Aminophenylboric acid

产物 1

HCID 183615236-(3'-Aminobiphenyl-4-yl)methoxy-2-[2-(N,N-dimethylamino)ethyl]tetralin hydrochloride

试剂、催化剂与溶剂 3

HCID 11979704四三苯基膦钯催化剂HCID 702乙醇溶剂HCID 1140甲苯溶剂

实验过程

An ethanol solution (10 ml) of 3-aminophenylboric acid (1.3 g) and an aqueous 2M sodium carbonate solution (10 ml) were added to a toluene solution (80 ml) of 6-(4-bromobenzyl)oxy-2-[2-(N,N-dimethylamino)ethyl]tetralin (3.00 g) and tetrakis(triphenylphosphine) palladium (0.45 g). The reaction mixture was heated under reflux for 12 hours in an argon atmosphere. A saturated aqueous sodium chloride solution was added to this, which was then extracted with ethyl acetate. The organic layer was dried, and then concentrated. The residue was purified by alumina column chromatography (eluent:ethyl acetate/hexane=1/2), and then processed with 4 N hydrochloric acid-ethyl acetate to form a hydrochloride. The thus-formed salt was recrystallized from methanol-diisopropyl ether to obtain the entitled compound (0.78 g).

后处理

  1. temperatureThe reaction mixture was heated
  2. temperatureunder reflux for 12 hours in an argon atmosphere
  3. extractionwas then extracted with ethyl acetate
  4. customThe organic layer was dried
  5. concentrationconcentrated
  6. customThe residue was purified by alumina column chromatography (eluent:ethyl acetate/hexane=1/2)

来源与证据

ORD记录
ord-bf4405f3807a4f0686ddbaae540eb835
来源数据集
uspto-grants-2007_08
专利号
US07256204B2

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