海萝胶 → 2-Acetamido-6-methylbenzoic acid

HRID 861816

反应方程式

HRID 861816 反应方程式
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([NH2:11])[C:7]=1[C:8]([OH:10])=[O:9].[OH-].[Na+].[C:14](OC(=O)C)(=[O:16])[CH3:15].Cl>O>[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([NH:11][C:14](=[O:16])[CH3:15])[C:7]=1[C:8]([OH:10])=[O:9]

参与物

6

反应物 4

HCID 313海萝胶HCID 7918乙酐HCID 14798二甲基对苯二胺二盐酸HCID 1512102-氨基-6-甲基苯甲酸

产物 1

HCID 28014002-Acetamido-6-methylbenzoic acid

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

90.6 g (0.6 mol) of 6-methylanthranilic acid are added to a solution of 24.8 g (0.62 mol) of NaOH in 500 ml of water and 63.4 g (0.62 mol) of acetic anhydride are then added dropwise. After stirring for one hour, the mixture is acidified to pH 3 with conc. HCl with cooling, and the precipitate which deposits is filtered off with suction, washed with water and dried under reduced pressure at 50° C. Yield: 107 g (0.55 mol)=92% of theory, m.p.: 189°-190° C.

后处理

  1. additionare then added dropwise
  2. temperaturewith cooling
  3. filtrationthe precipitate which deposits is filtered off with suction
  4. washwashed with water
  5. customdried under reduced pressure at 50° C

来源与证据

ORD记录
ord-2ddc99d5ca554895938e35503c3129e7
来源数据集
uspto-grants-1998_02
专利号
US05716905

关联笔记

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