聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] → 2-(1-苄基吡咯烷-3-基)乙腈

HRID 866

反应方程式

HRID 866 反应方程式
[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13]Cl)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C-:15]#[N:16].[Na+].O>CS(C)=O>[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13][C:15]#[N:16])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参与物

5

反应物 3

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]HCID 8929氰化钠HCID 123645181-苄基-3-(氯甲基)吡咯烷

产物 1

HCID 123645192-(1-苄基吡咯烷-3-基)乙腈收率 92%

试剂、催化剂与溶剂 1

HCID 679二甲基亚砜溶剂

反应条件

温度
60 °C

实验过程

16.8 g (0.08 mole) (3RS)-1-benzyl-3-chloromethyl pyrrolidine and 5.88 g (0.12 mole) of sodium cyanide was dissolved in 250 ml dimethyl sulfoxide. The mixture was stirred at 60° C. for two days and at room temperature for one week. Water was added and the mixture was extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried (Na2SO4), filtered and evaporated to yield 14.7 g (92%) of the product.

后处理

  1. extractionthe mixture was extracted three times with ethyl acetate
  2. washThe combined organic layer was washed with brine
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. customevaporated

来源与证据

ORD记录
ord-56818a6d757b4766865fa51ce27de994
来源数据集
uspto-grants-1998_03
专利号
US05723444

关联笔记

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