参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | (S)-(+)-2-氨基-1-戊醇 | HCID 6951248 | — |
| 反应物 | 2-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)phenyl)acetonitrile | HCID 87444782 | — |
| 试剂 | 碳酸钾 | HCID 11430 | — |
| 催化剂 | 4,5-双二苯基膦-9,9-二甲基氧杂蒽 | HCID 636044 | — |
| 催化剂 | 醋酸钯 | HCID 4144353 | — |
| 溶剂 | 1,4-二氧六环 | HCID 31275 | — |
| 产物 | 2-[4-[[2-amino-4-[[(2S)-1-hydroxypentan-2-yl]amino]-6-methylpyrimidin-5-yl]methyl]phenyl]acetonitrile | HCID 68955774 | 0% |
反应步骤
Palladium(II) acetate (8.23 mg, 0.04 mmol) and 9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene (42.4 mg, 0.07 mmol) were added to dioxane (3 mL) and the solution was stirred at room temperature for 10 minutes. 2-(4-((2-amino-4-chloro-6-methylpyrimidin-5-yl)methyl)phenyl)acetonitrile (200 mg, 0.73 mmol), (S)-(+)-2-Amino-1-pentanol (151 mg, 1.47 mmol) and POTASSIUM CARBONATE (203 mg, 1.47 mmol) were added and the mixture was heated at 100 °C for 15 hours. LCMS showed no product and reaction not progressed.
来源与证据
| 来源数据集 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-d1855bc74886445fbdfc0eab57bed8cb |
|---|
| 来源说明 | 750 AstraZeneca ELN dataset |
|---|
