(S)-(+)-2-氨基-1-戊醇 → 2-[4-[[2-amino-4-[[(2S)-1-hydroxypentan-2-yl]amino]-6-methylpyrimidin-5-yl]methyl]phenyl]acetonitrile

HRID 87

反应方程式

HRID 87 反应方程式
CCC[C@H](N)CO.Cc1nc(N)nc(Cl)c1Cc1ccc(CC#N)cc1>C1COCCO1.CC(=O)O.CC(=O)O.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.O=C([O-])[O-].[K+].[K+].[Pd]>CCC[C@@H](CO)Nc1nc(N)nc(C)c1Cc1ccc(CC#N)cc1

参与物

7

反应物 2

HCID 6951248(S)-(+)-2-氨基-1-戊醇HCID 874447822-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)phenyl)acetonitrile

产物 1

HCID 689557742-[4-[[2-amino-4-[[(2S)-1-hydroxypentan-2-yl]amino]-6-methylpyrimidin-5-yl]methyl]phenyl]acetonitrile收率 0%

试剂、催化剂与溶剂 4

HCID 11430碳酸钾试剂HCID 6360444,5-双二苯基膦-9,9-二甲基氧杂蒽催化剂HCID 4144353醋酸钯催化剂HCID 312751,4-二氧六环溶剂

反应条件

温度
100 °C

实验过程

Palladium(II) acetate (8.23 mg, 0.04 mmol) and 9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene (42.4 mg, 0.07 mmol) were added to dioxane (3 mL) and the solution was stirred at room temperature for 10 minutes. 2-(4-((2-amino-4-chloro-6-methylpyrimidin-5-yl)methyl)phenyl)acetonitrile (200 mg, 0.73 mmol), (S)-(+)-2-Amino-1-pentanol (151 mg, 1.47 mmol) and POTASSIUM CARBONATE (203 mg, 1.47 mmol) were added and the mixture was heated at 100 °C for 15 hours. LCMS showed no product and reaction not progressed.

来源与证据

ORD记录
ord-d1855bc74886445fbdfc0eab57bed8cb
来源数据集
750 AstraZeneca ELN dataset
原始链接
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