甲酸甲酯 → N-甲酰基甘氨酸乙酯

HRID 877656

反应方程式

HRID 877656 反应方程式
Cl.[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3].[CH:9](OC)=[O:10]>C(N(CC)CC)C>[CH:9]([NH:7][CH2:6][C:5]([O:4][CH2:2][CH3:3])=[O:8])=[O:10]

参与物

4

反应物 2

HCID 7865甲酸甲酯HCID 2723640甘氨酸乙酯盐酸盐

产物 1

HCID 76615N-甲酰基甘氨酸乙酯收率 93%

试剂、催化剂与溶剂 1

HCID 8471三乙胺溶剂

实验过程

To a 5 L three neck round bottom flask equipped with a mechanic stirrer, a pressure-equalizing funnel and a condenser bearing a calcium chloride drying tube was added glycine ethyl ester hydrochloride (500 g, 3.583 mol) and methyl formate (1.8 L). The suspension was brought to reflux and triethylamine (556 mL) was added to the reaction. The reaction was stirred and refluxed overnight. The reaction was cooled to room temperature and filtered through a Buchner funnel to remove triethylamine hydrochloride salt. The filtrate was concentrated and dried over high vacuum to yield 320 g (93%) of the title compound.

后处理

  1. temperatureto reflux
  2. temperaturerefluxed overnight
  3. filtrationfiltered through a Buchner funnel
  4. customto remove triethylamine hydrochloride salt
  5. concentrationThe filtrate was concentrated
  6. customdried over high vacuum

来源与证据

ORD记录
ord-a65f2f54fff342d3966946a9c29b79b0
来源数据集
uspto-grants-2015_03
专利号
US08987268B2

关联笔记

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