氨 → 2-喹啉甲胺

HRID 911345

反应方程式

HRID 911345 反应方程式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]#[N:12].N>CO.[Ni]>[NH2:12][CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:1]=1

参与物

5

反应物 2

HCID 222氨HCID 740312-氰基喹啉

产物 1

HCID 30143782-喹啉甲胺收率 98%

试剂、催化剂与溶剂 2

HCID 935Nickel催化剂HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

实验过程

Combine quinoline-2-carbonitrile (0.2 g, 1.29 mmol), Raney® 3201 nickel (slurry in water, 0.05 g), 2N ammonia in methanol (10 mL) and hydrogenate at 50 psi for 15 min. Filter the reaction mixture through a pad of Celite®, remove the solvent and purify by SCX chromatography to obtain the title compound as a yellow oil (0.2 g, 98%). MS (ES+) m/z: 159 (M+H)+.

后处理

  1. filtrationFilter the reaction mixture through a pad of Celite®
  2. customremove the solvent
  3. custompurify by SCX chromatography

来源与证据

ORD记录
ord-839a12ee421c44b4a9eb6fc8d4fa86b5
来源数据集
uspto-grants-2011_09
专利号
US08022062B2

关联笔记

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