3,5-二溴吡啶 → 3,5-二溴吡啶氮氧化物-1
反应方程式
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Br:8])[CH:7]=1.ClC1C=CC=C(C(OO)=[O:17])C=1>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[N+:4]([O-:17])[CH:5]=[C:6]([Br:8])[CH:7]=1参与物
4
试剂、催化剂与溶剂 1
实验过程
3,5-Dibromopyridine 2.37 g is dissolved in methylene chloride 25 ml and thereto is added m-chloroperbenzoic acid 2.96 g at room temperature under stirring. After stirring for 5 hours at room temperature, additional m-chloroperbenzoic acid 246 mg is added thereto and the mixture is stirred. After 15 hours the solvent is removed in vacuo and the residue is purified by silica gel chromatography (solvent; n-hexane:ethyl acetate=1:1) to give 3,5-dibromopyridine N-oxide as colorless crystals, 2.26 g. mp 140-142° C.
后处理
- stirringAfter stirring for 5 hours at room temperature
- stirringthe mixture is stirred
- customAfter 15 hours the solvent is removed in vacuo
- customthe residue is purified by silica gel chromatography (solvent; n-hexane:ethyl acetate=1:1)
来源与证据
- ORD记录
- ord-4588c7ebedeb496eb9089a9308afeb58
- 来源数据集
- uspto-grants-2007_09
- 专利号
- US07273868B2
反应笔记
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