三乙胺 → HCID 68156975，化合物

HRID 921375

反应方程式

HRID 921375 反应方程式
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([P:15]([CH3:18])([CH3:17])=[O:16])=[CH:11][CH:10]=2)[CH:3]=1.C(N(CC)CC)C.Cl.[NH2:27][N:28]1[CH2:35][CH:34]2[CH:30]([CH2:31][CH2:32][CH2:33]2)[CH2:29]1>C(O)C>[CH3:17][P:15]([C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:4]2[CH:3]=[C:2]([NH:27][N:28]3[CH2:35][CH:34]4[CH2:33][CH2:32][CH2:31][CH:30]4[CH2:29]3)[N:7]=[CH:6][N:5]=2)=[CH:10][CH:11]=1)([CH3:18])=[O:16]

参与物

5

反应物 3

HCID 8471三乙胺HCID 16213802N-氨基-3-氮杂双环[3.3.0]辛烷盐酸盐HCID 86668807HCID 86668807，化合物

产物 1

HCID 68156975HCID 68156975，化合物

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

To a solution of 6-chloro-N-[4-(dimethylphosphoryl)phenyl]pyrimidin-4-amine (prepared as in Example 59: 0.12 mmol) in 2 mL of ethanol is added 50 L of triethylamine and 3-Amino-3-azabicyclo-[3,3,0]octane hydrochloride salt (19 mg, 0.12 mmol). The mixture is microwaved at 120 degrees until formation of the desired compound. The reaction mixture can then be filtered through a syringe filter and purified by prep-HPLC.

来源与证据

ORD记录
ord-bd12bc48c8f34c27ab362c3bac4531c6
来源数据集
uspto-grants-2016_03
专利号
US09273077B2

关联笔记

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