四丁基氟化铵 → 2,6-Dipropyl-4-(2-hydroxyethyl)phenol

HRID 964458笔记

反应方程式

HRID 964458 反应方程式
[Si]([O:8][C:9]1[C:14]([CH2:15][CH2:16][CH3:17])=[CH:13][C:12]([CH2:18][CH2:19][OH:20])=[CH:11][C:10]=1[CH2:21][CH2:22][CH3:23])(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[CH2:21]([C:10]1[CH:11]=[C:12]([CH2:18][CH2:19][OH:20])[CH:13]=[C:14]([CH2:15][CH2:16][CH3:17])[C:9]=1[OH:8])[CH2:22][CH3:23]

参与物

4

反应物 2

HCID 2724141四丁基氟化铵HCID 19080442t-Butyldimethylsilyloxy-2,6-dipropyl-4-(2-hydroxyethyl)-benzene

产物 1

HCID 190803732,6-Dipropyl-4-(2-hydroxyethyl)phenol收率 170.6%

试剂、催化剂与溶剂 1

HCID 8028四氢呋喃溶剂2 次

实验过程

To a solution of 1.0 g (2.98 mmol) of the product of Step C in 3.0 mL of THF was added 3.57 mL (3.57 mmol) of 1.0N solution of tetrabutylammonium fluoride in THF. After 15 minutes TLC indicated that the reaction was complete. The reaction mixture was concentrated and then purified by flash chromatography (silica gel, hexane/ethyl acetate 3:1) to give 1.13 g of the title compound.

后处理

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by flash chromatography (silica gel, hexane/ethyl acetate 3:1)

来源与证据

ORD记录
ord-12ae317766c64999bd88ae188a0b1199
来源数据集
uspto-grants-1998_06
专利号
US05767310

反应笔记

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