1,3-二甲基-4-硝基-1H-吡唑-5-甲酰胺 → 4-氨基-1,3-二甲基-1H-吡唑-5-甲酰胺

HRID 979051

反应方程式

HRID 979051 反应方程式
[CH3:1][N:2]1[C:6]([C:7]([NH2:9])=[O:8])=[C:5]([N+:10]([O-])=O)[C:4]([CH3:13])=[N:3]1>CO.[Ni]>[CH3:1][N:2]1[C:6]([C:7]([NH2:9])=[O:8])=[C:5]([NH2:10])[C:4]([CH3:13])=[N:3]1

参与物

4

反应物 1

HCID 12297641,3-二甲基-4-硝基-1H-吡唑-5-甲酰胺

产物 1

HCID 138229254-氨基-1,3-二甲基-1H-吡唑-5-甲酰胺

试剂、催化剂与溶剂 2

HCID 935Nickel催化剂HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

实验过程

Fifty g of 1,3-dimethyl-4-nitropyrazole-5-carboxamide dissolved in methanol, 2 g 50% aqueous Raney nickel added, was reduced under a hydrogen atmosphere until a 8.15 pound drop in pressure noted. The reaction mixture was filtered, the filtrate concentrated, and the crude material recrystallized in ethyl acetate to yield the product, mp. 154°-155° C.

后处理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate concentrated
  3. customthe crude material recrystallized in ethyl acetate
  4. customto yield the product, mp. 154°-155° C.

来源与证据

ORD记录
ord-231270a024cf493e8fd62695d19e81c8
来源数据集
uspto-grants-1987_05
专利号
US04666908

关联笔记

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