HCID441374

Kanamycin A Sulfate

(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid

C18H38N4O15S582.6 g/molCAS 25389-94-0

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IDENTITY

结构与身份

标准SMILES: NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O.O=S(=O)(O)O
InChIKey: OOYGSFOGFJDDHP-KMCOLRRFSA-N
分子式: C18H38N4O15S
平均分子量: 582.6 g/mol
单同位素质量: 582.20543769

COMPUTED

结构计算性质

已同步

极性表面积: 366 Å²
氢键供体: 13
氢键受体: 19
可旋转键: 6
重原子: 38
形式电荷: 0
复杂度: 720

PROPERTIES

实验与物化性质

Collision Cross Section

221.1 Å² [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS

GHS分类

GHS Classification

This chemical does not meet GHS hazard criteria for 1% (1 of 96) of reports.

Danger

H360 (69.8%): May damage fertility or the unborn child [Danger Reproductive toxicity]；H372 (29.2%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]；H400 (29.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410 (29.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P260, P264, P270, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 96 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 1 of 96 reports by companies.；There are 9 notifications provided by 95 of 96 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

HAZARDS

危害信息

Hazard Classes and Categories

Repr. 1B (69.8%)；STOT RE 1 (29.2%)；Aquatic Acute 1 (29.2%)；Aquatic Chronic 1 (29.2%)

Repr. 1B (100%)

USES

用途与制造

Use Classification

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

ALIASES

名称与别名

共 123 条

Kanamycin A sulfateKanamycin A sulphateDTXSID1047524J80EX28SMQEINECS 223-347-1(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acidCHEBI:6109DTXCID9027524KANAMYCIN A SULFATE [MI]KANAMYCIN SULFATE [USP-RS]KANAMYCIN SULFATE [USP MONOGRAPH]KANAMYCIN MONOSULFATE [EP MONOGRAPH]KANAMYCIN SULFATE (USP-RS)KANAMYCIN SULFATE (USP MONOGRAPH)D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->4))-2-DEOXY-, SULFATE (1:1) (SALT)D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->4))-2-DEOXY-, SULPHATE (1:1) (SALT)D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl(1->4))-2-deoxy-, sulfate (1:1) (salt)KANAMYCIN MONOSULFATE (EP MONOGRAPH)Kanaplex(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-((1R,2R,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy-2-hydroxycyclohexyl)oxyoxane-3,4,5-triol;sulfuric acid

REACTIONS