结构:CC(=O)[O-].[K+]
HCID517044

Potassium Acetate

C2H3KO298.14 g/molCAS 127-08-2

IDENTITY

结构与身份

标准 SMILES
CC(=O)[O-].[K+]
InChIKey
SCVFZCLFOSHCOH-UHFFFAOYSA-M
分子式
C2H3KO2
平均分子量
98.14 g/mol
单同位素质量
97.97701082

COMPUTED

结构计算性质

已同步
极性表面积
40.1 Ų
氢键供体
0
氢键受体
2
可旋转键
0
重原子
5
形式电荷
0
复杂度
34

PROPERTIES

实验与物化性质

来源:PubChem
pH

7,5-9,0 (5 % aqueous solution)

Density

1.6 g/cm³

1.57 @25 °C

Solubility

Solubility in water, g/100ml at 20 °C: 256

Melting Point

292 °C

309 °C

Physical Description

CBI; Large Crystals; Dry Powder; Liquid; Dry Powder; Large Crystals

Colourless, deliquescent crystals or a white crystalline powder, odourless or with a faint acetic odour

Lustrous colorless or white solid; Rapidly deliquescent; [Merck Index] White crystalline solid; [Aldrich MSDS]

WHITE FLAKES OR CRYSTALLINE POWDER.

GHS

GHS 分类

来源:PubChem
GHS Classification

This chemical does not meet GHS hazard criteria for 87.3% (418 of 479) of all reports.

Warning

H315 (11.5%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (12.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (11.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 479 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 418 of 479 reports by companies.;There are 9 notifications provided by 61 of 479 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

HAZARDS

危害信息

来源:PubChem
Regulatory Information

Chemical: Acetic acid, potassium salt

Acetic acid, potassium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, potassium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 21-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15104

Potassium acetate: Non hazardous

Other Safety Information

IMAP assessments - Acetic acid, potassium salt: Human health tier I assessment

Fire Hazards

Combustible.

Hazards Summary

A mild skin and eye irritant; [ICSC] Not irritating to eyes of rabbits; [IUCLID] Allowable daily intake (ADI) of not limited [JECFA] May cause irritation; [Aldrich MSDS]

EPA Safer Chemical

Chemical: Potassium acetate; Green circle - The chemical has been verified to be of low concern based on experimental and modeled data.

Chemical Dangers

Decomposes on heating and on contact with strong acids. This produces acetic acid fumes. Reacts violently with strong oxidants. The solution in water is a weak base.

Hazard Classes and Categories

Skin Irrit. 2 (11.5%);Eye Irrit. 2 (12.7%);STOT SE 3 (11.5%)

Not Classified

SAFETY

安全与防护

来源:PubChem
Fire Fighting

Use water spray, foam, powder, carbon dioxide.

First Aid Measures

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rest.

Safe Storage

Separated from strong acids and strong oxidants.

Spillage Disposal

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

Eye Prevention

Wear safety goggles.

Fire Prevention

NO open flames.

Inhalation Risk

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached.

Skin Prevention

Protective gloves.

Ingestion Prevention

Do not eat, drink, or smoke during work.

Inhalation Prevention

Use local exhaust.

Effects of Short Term Exposure

The substance is mildly irritating to the eyes and skin.

Protective Action Criteria (PAC)

9.8 [mg/m3]

110 [mg/m3]

640 [mg/m3]

TOXICITY

毒理信息

来源:PubChem
Exposure Routes

The substance can be absorbed into the body by ingestion.

Toxicity Summary

Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

Signs and Symptoms

Redness.

Redness.

REGULATORY

法规信息

来源:PubChem
Regulatory Information

Chemical: Acetic acid, potassium salt

Acetic acid, potassium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, potassium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 21-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15104

Potassium acetate: Non hazardous

PHARMACOLOGY

药理信息

来源:PubChem
ATC Code

B - Blood and blood forming organs;B05 - Blood substitutes and perfusion solutions;B05X - I.v. solution additives;B05XA - Electrolyte solutions;B05XA17 - Potassium acetate

QB - Blood and blood forming organs;QB05 - Blood substitutes and perfusion solutions;QB05X - I.v. solution additives;QB05XA - Electrolyte solutions;QB05XA17 - Potassium acetate

Mechanism of Action

Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium is maintained by ion pumps in the cell membrane. The cell membrane potential created by potassium and sodium ions allows the cell generate an action potential—a "spike" of electrical discharge. The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle contraction, and heart function. Potassium is also an essential mineral needed to regulate water balance, blood pressure and levels of acidity.

FDA Pharmacological Classification

KALI ACETICUM

Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Activity [MoA]; Increased Large Intestinal Motility [PE]; Potassium Salt [EPC]; Potassium Compounds [CS]; Osmotic Laxative [EPC]

POTASSIUM ACETATE

Potassium Compounds [CS]; Osmotic Laxative [EPC]; Increased Large Intestinal Motility [PE]; Potassium Salt [EPC]; Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Activity [MoA]

Absorption, Distribution and Excretion

Mostly urine but also skin and feces.

USES

用途与制造

来源:PubChem
Uses

CIR ingredient: Potassium Acetate

Used as a potassium supplement; [Merck Index] Used in the chemical industry (synthesis), textile processing industry, anti-freeze agents, foods (permitted additive in the UK), and pharmaceuticals; Also used as a pH regulator and industrial de-icer; [IUCLID] Used in foods as a buffer and antimicrobial preservative; [JECFA] Used as a dehydrating agent and in crystal glass; [Hawley]

Textiles (Fiber & Fabric Manufacturing) [Category: Industry];Glass Manufacturing [Category: Industry]

U.S. Production

2023: 250,000,000 - <400,000,000 lb;2022: 250,000,000 - <400,000,000 lb;2021: 250,000,000 - <400,000,000 lb;2020: 100,000,000 - <250,000,000 lb

Consumer Uses

Anti-scaling agent;Not Known or Reasonably Ascertainable;Soil amendments (fertilizers);Preservative;Flame retardant;Lubricating agent;Other;Anti-freeze agent

Industry Uses

Chemical reaction regulator;pH regulating agent;Other;Lubricating agent;Anti-freeze agent;Defoamer;Laboratory chemicals;Intermediate;Preservative;Soil amendments (fertilizers);Catalyst;Corrosion inhibitor;Not Known or Reasonably Ascertainable;Flame retardant

Household Products

Information on 3 consumer products that contain Potassium Acetate in the following categories is provided:;• Inside the Home

Use Classification

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

Food additives

Food Additives -> ACIDITY_REGULATOR; PRESERVATIVE -> JECFA Functional Classes

Cosmetics -> Film forming

General Manufacturing Information

Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing;Soap, Cleaning Compound, and Toilet Preparation Manufacturing;Wholesale and Retail Trade;Agriculture, Forestry, Fishing and Hunting;Plastics Material and Resin Manufacturing;Not Known or Reasonably Ascertainable;Construction;All Other Chemical Product and Preparation Manufacturing;Miscellaneous Manufacturing;Food, beverage, and tobacco product manufacturing;All Other Basic Organic Chemical Manufacturing

Acetic acid, potassium salt (1:1): ACTIVE

ALIASES

名称与别名

97
Potassium acetate127-08-2Diuretic saltACETIC ACID, POTASSIUM SALTAcetic acid, potassium salt (1:1)Potassium ethanoateFEMA No. 2920Octan draselnyKali aceticumPotassium acetatesDTXSID7027043Potassium acetate in plastic containerINS NO.261E261INS-261INS-261(I)DTXCID107043E-261M911911U02CHEBI:32029

REACTIONS

参与反应

3,041