Hydrochloric Acid → 4'-Decyloxybiphenyl-4-carboxylic Acid

HRID 1417

反応式

HRID 1417 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH2:17](Br)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26].[OH-].[K+].[I-].[Na+].Cl>O.C(O)C>[CH2:17]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

参加物

8

反応物 5

HCID 313Hydrochloric AcidHCID 5238Sodium IodideHCID 81731-BromodecaneHCID 14797Potassium Hydroxide2 回HCID 3015564'-Hydroxy-4-biphenylcarboxylic acid

生成物 1

HCID 114510854'-Decyloxybiphenyl-4-carboxylic Acid収率 6%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

反応条件

温度
100 °C

実験手順

A mixture of 21.4 g (0.1 mol) of 4'-hydroxybiphenyl-4-carboxylic acid, 33.15 g (0.15 mol) of n-decyl bromide, 13.20 g (0.2 mol) of 85% potassium hydroxide, 1.05 g (7 mmol) of sodium iodide, 500 ml of ethanol and 100 ml of distilled water was heated under reflux at 100° C. for 12 hours. After 40 ml of 25% potassium hydroxide was added, the mixture was further heated under reflux for 2 hours. After allowing the reaction system to cool up to room temperature, the reaction mixture in cold water was acidified with 36% hydrochloric acid. The deposited product was separated by filtration and dissolved in acetone with heating, followed by filtration. The resulting filtrate was concentrated to obtain 1.97 g (6 mmol) of 4'-decyloxybiphenyl-4-carboxylic acid.

後処理

  1. temperaturewas heated
  2. temperaturethe mixture was further heated
  3. temperatureunder reflux for 2 hours
  4. temperatureto cool up to room temperature
  5. customThe deposited product was separated by filtration
  6. dissolutiondissolved in acetone
  7. temperaturewith heating
  8. filtrationfollowed by filtration
  9. concentrationThe resulting filtrate was concentrated

出典と根拠

ORDレコード
ord-0396fca3395e4ebeb8f2c15f2dea83c8
出典データセット
uspto-grants-1998_03
特許番号
US05725798

関連ノート

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