Dihydralazin

Dihydralazine

HCID 10230CAS 484-23-1
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Grundinformationen

Standard-SMILES
NNc1nnc(NN)c2ccccc12
InChIKey
VQKLRVZQQYVIJW-UHFFFAOYSA-N
Summenformel
C8H10N6
Durchschnittliche Molmasse
190,21 g/mol
Monoisotopische Masse
190,09669434

Namen und Bezeichner

Bevorzugter Name
Dihydralazine
IUPAC
(4-hydrazinylphthalazin-1-yl)hydrazine
Lokaler Name
Dihydralazin
Englischer Name
Dihydralazine
Summenformel
C8H10N6
Molmasse
190.21

Namen und Synonyme

DIHYDRALAZINE484-23-11,4-DihydrazinophthalazineDihydrallazinDihydrallazineHypopresol1,4-dihydrazinylphthalazineDihydrazinophthalazineDihidralazinaDihydralazinum2,3-Dihydro-1,4-phthalazinedione dihydrazoneC 7441
Weitere Namen anzeigen
c7441C8H1ON6nepresolOphthazintonolysinnepressolnepresolinNSC 526654
DTXSID00229351,4-Phthalazinedione, 2,3-dihydro-, dihydrazoneNSC-526654PCU411F5L6DTXCID902935NSC526654Dihydrazinophthalazindiidralazina

Datenbank-Bezeichner

CAS
484-23-1
PubChem CID
10230
DTXSID
DTXSID0022935
ChEMBL
CHEMBL35505
ChEBI
CHEBI:134841
UNII
PCU411F5L6
EC Number
207-605-0
Nikkaji
J5.994C

Eigenschaften

Berechnete Struktureigenschaften

XLogP
0,2
Polarare Oberfläche (TPSA)
102 Ų
H-Brücken-Donoren
4
H-Brücken-Akzeptoren
6
Frei drehbare Bindungen
2
Schwere Atome
14

Physikochemische Eigenschaften

Schmelzpunkt
180 °C · 180°C (rough estimate)
Siedepunkt
315.71 °C · 315.71°C (rough estimate)
Dichte
1.3243 · 1.3243 (rough estimate)
Brechungsindex
1.81 · 1.8100 (estimate)
pka
3 · 3+-.0.20(Predicted)
Farbe
2 O · Orange crystals from H2O

Sicherheit und Regulatorisches

Gefahrenhinweise

Other Safety InformationIMAP assessments - 1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone: Environment tier I assessment；IMAP assessments - 1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone: Human health tier I assessment

Sicherheitsdaten

hs_code
2933998090
Toxizität
LD50 i.p. in rats: 1084 mmol/kg (Steiner)

Chemie und Industrie

Pharmakologische Informationen

ATC Code · 2 Einträge

C - Cardiovascular system；C02 - Antihypertensives；C02D - Arteriolar smooth muscle, agents acting on；C02DB - Hydrazinophthalazine derivatives；C02DB01 - Dihydralazine

QC - Cardiovascular system；QC02 - Antihypertensives；QC02D - Arteriolar smooth muscle, agents acting on；QC02DB - Hydrazinophtalazine derivatives；QC02DB01 - Dihydralazine

MeSH Pharmacological Classification · 1 Eintrag

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Verwendung und Herstellung

UsesUse (kg; approx.) in Germany (2009): >500；Consumption (g per capita; approx.) in Germany (2009): 0.00611；Calculated removal (%): 75.1

Anwendungen

VerwendenOphthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.

Darstellung

synthetischeDihydralazine is prepared from dichlorophthalazine via sequential substitution and hydrazination reactions. ​

Vor- und nachgelagerte Produkte

Anbieter17 Anbieter

杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]

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