HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dihydralazin
DIHYDRALAZINE · c7441 · C8H1ON6 · nepresol · Ophthazin · tonolysin · nepressol · hypopresol
Identifikatoren & physikalische Daten
| CAS No. | 484-23-1 |
|---|---|
| Summenformel | C8H10N6 |
| Durchschnittliche Molmasse | 190,21 g/mol |
| Monoisotopische Masse | 190,09669434 g/mol |
| SMILES | NNc1nnc(NN)c2ccccc12 |
| InChIKey | VQKLRVZQQYVIJW-UHFFFAOYSA-N |
| PubChem CID | 10230 |
| ChEMBL | CHEMBL35505 |
| ChEBI | CHEBI:134841 |
| EC No. | 207-605-0 |
| DTXSID | DTXSID0022935 |
| Lokaler Name | Dihydralazin |
Chemische & physikalische Eigenschaften
| XLogP | 0,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 102 |
| H-Brücken-Donoren | 4 |
| H-Brücken-Akzeptoren | 6 |
| Frei drehbare Bindungen | 2 |
| Schwere Atome | 14 |
| Formalladung | 0 |
| Komplexität | 167 |
| Schmelzpunkt | 180°C (rough estimate) |
| Siedepunkt | 315.71°C (rough estimate) |
| Dichte | 1.3243 (rough estimate) |
| Brechungsindex | 1.8100 (estimate) |
| pKa (Säurekonstante) | 3+-.0.20(Predicted) |
| Farbe | Orange crystals from H2O |
Sicherheit & Vorschriften
| Weitere Sicherheitsinformationen | IMAP assessments - 1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone: Environment tier I assessmentIMAP assessments - 1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone: Human health tier I assessment |
|---|---|
| Zollcode | 2933998090 |
| Toxizität | LD50 i.p. in rats: 1084 mmol/kg (Steiner) |
Anwendungen & Verwendung
Verwenden
Ophthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.
Herstellung & Synthese
synthetische
Dihydralazine is prepared from dichlorophthalazine via sequential substitution and hydrazination reactions.