Formamidinmonoacetat
Iminomethanaminium acetate
Grundinformationen
- CAS
3473-63-0- Standard-SMILES
CC(=O)[O-].NC=[NH2+]- InChIKey
XPOLVIIHTDKJRY-UHFFFAOYSA-N- Summenformel
- C3H8N2O2
- Durchschnittliche Molmasse
- 104,11 g/mol
- Monoisotopische Masse
- 104,0585775
Überblick
See also: Formamidine acetate (preferred).
Namen und Bezeichner
- Bevorzugter Name
- Iminomethanaminium acetate
- IUPAC
- aminomethylideneazanium acetate
- Lokaler Name
- Formamidinmonoacetat
- Englischer Name
- Formamidine acetate
- Summenformel
- C3H8N2O2
- Molmasse
- 104.11
Namen und Synonyme
Iminomethanaminium acetateFormamidine acetate (1:1)DTXSID3063047forMiMidaMide acetateFAACB3408896Formamidinium acetateFORMAMIDINE ACETATE SALTIMINOFORMAMIDE ACETATEMethanimidamide(9CI)ormamidine acetateMethanimidamide monoacetate
Weitere Namen anzeigen
FORMAMIDINE ACETIC ACID SALT
Datenbank-Bezeichner
- CAS
3473-63-0- PubChem CID
- 10285782
- DTXSID
DTXSID3063047
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 91,7 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 2
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 7
- Formalladung
- 0
- Komplexität
- 33
Physikochemische Eigenschaften
- Schmelzpunkt
- 161 °C · 161 °C
- Dichte
- 1.124 · 1.124
- Flammpunkt
- Not applicable
- storage temp.
- 30 °C · Store below +30°C.
- Löslichkeit
- 832 g/l · 832g/l
- Aggregatzustand
- powder to crystal
- Farbe
- White to Almost white
- PH
- 8 · 8 (400g/l, H2O, 20℃)
- Wasserlöslichkeit
- 832 g/L · 832 g/L (21 ºC)
- BRN
- 3563488 · 3563488
- InChI
- InChI=1S/C2H4O2.CH4N2/c1-2(3)4;2-1-3/h1H3,(H,3,4);1H,(H3,2,3)
- InChIKey
- XPOLVIIHTDKJRY-UHFFFAOYSA-N
- SMILES
- C(C)(=O)O.C(=N)N
- CAS Datenbank
- 3473 · 3473-63-0(CAS DataBase Reference)
- EPA chemische Informationen
- Methanimidamide, monoacetate (3473-63-0)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- F
- 3-9-21
- wgk
- 2
- tsca
- TSCA listed
- hs_code
- 29252000
- risk_code
- 43-36/37/38
- Toxizität
- LD50 orally in Rabbit: 2510 mg/kg LD50 dermal Rat > 2000 mg/kg
- hazard_code
- Xi
- safety_code
- 36/37-37/39-26-36/37/39-27
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Skin Sens. 1
- Selbstentzündungstemperatur
- 565 °C
Chemie und Industrie
Anwendungen
BeschreibungFormamidine acetate is an anti-tuberculosis drug that belongs to the class of aminoglycosides. It has been shown to have a potent cytotoxic effect on malignant brain cells in vitro. It inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. It also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.
VerwendenFormamidine acetate is used as an intermediate in the synthesis of active pharmaceutical ingredients. It is also used as a condensing agent for the preparation of pyrimidine and imidazole heterocycles.
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