5-Bromoisatoic Anhydride → 6-bromoquinazolin-4-ol

HRID 40239Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 40239
[Br:1][C:2]1[CH:13]=[C:6]2[C:7](O[C:10](=O)[NH:11][C:5]2=[CH:4][CH:3]=1)=[O:8].C([O-])(=O)C.C(N)=[NH2+:19]>CC(O)C>[Br:1][C:2]1[CH:13]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:11]=[CH:10][NH:19][C:7]2=[O:8]

Komponenten

4

Edukt 2

HCID 2885615-Bromoisatoic AnhydrideHCID 10285782Iminomethanaminium acetate

Produkt 1

HCID 1354449056-bromoquinazolin-4-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A solution of 5-bromoisatoic anhydride (5.0 g, 21 mmol) and formamidinium acetate (2.2 g, 21 mmol) in 60 mL of i-PrOH was heated at reflux for 10 hours. The reaction mixture was cooled to rt and the white solid was collected by filtration. The white solid was washed with small amount of i-PrOH and dried in air to give desired product 6-bromoquinazolin-4(3H)-one. MS (ESI, pos. ion) m/z: 224.9 (M+1).

Aufarbeitung

  1. temperatureat reflux for 10 hours
  2. filtrationthe white solid was collected by filtration
  3. washThe white solid was washed with small amount of i-PrOH
  4. customdried in air

Quellen und Nachweise

ORD-Eintrag
ord-153754fc21ba4e269689d52dcd513510
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524900B2

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