1,2-Epoxy-3-fluorpropan

Oxirane, (fluoromethyl)- · WLN: T3OTJ B1F · Epifluorhydrine · EPIFLUOROHYDRIN · epifluorohydrine · cycloxyfluoropane · FLUOROMETHYLOXIRAN · Epifluorohydrin98%

https://huagongshe.com/de/chemical/10418

Molekülstruktur von 1,2-Epoxy-3-fluorpropan

Identifikatoren & physikalische Daten

CAS No.	503-09-3
Summenformel	C3H5FO
Durchschnittliche Molmasse	76,07 g/mol
Monoisotopische Masse	76,032443 g/mol
SMILES	FCC1CO1
InChIKey	OIFAHDAXIUURLN-UHFFFAOYSA-N
PubChem CID	10418
EC No.	207-960-1
DTXSID	DTXSID4025244
Lokaler Name	1,2-Epoxy-3-fluorpropan

Chemische & physikalische Eigenschaften

XLogP	-0,2
Polarare Oberfläche (TPSA)	12,5
H-Brücken-Donoren	0
H-Brücken-Akzeptoren	2
Frei drehbare Bindungen	1
Schwere Atome	5
Formalladung	0
Komplexität	37,9
SpringerMaterials Properties	Boiling point
LogP (Verteilungskoeffizient)	-0.16
Dichte	1.09 at 68 °F (NTP, 1992) - Denser than waterwill sink1.067 g/mL at 25 °C (lit.)
Löslichkeit	greater than or equal to 100 mg/mL at 61 °F (NTP, 1992)
Flammpunkt	40 °F (NTP, 1992)
Siedepunkt	185 to 187 °F at 760 mmHg (NTP, 1992)85-86 °C (lit.)
Physical Description	Epifluorohydrin is a clear colorless liquid. (NTP, 1992)
Brechungsindex	n20/D 1.368(lit.)
Lagerbedingungen	0-6°C
Aggregatzustand	liquid
Farbe	clear
InChI	InChI=1S/C3H5FO/c4-1-3-2-5-3/h3H,1-2H2
InChIKey	OIFAHDAXIUURLN-UHFFFAOYSA-N
SMILES	O1CC1CF
CAS Datenbank	503-09-3(CAS DataBase Reference)
NIST chemische Informationen	Oxirane, (fluoromethyl)-(503-09-3)
EPA chemische Informationen	Epifluorohydrin (503-09-3)

Sicherheit & Vorschriften

GHS-Einstufung	DangerH225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P270, P271, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P330, P361+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 44 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
DOT-Kennzeichnung	Flammable Liquid Poison
Brandgefahren	This chemical is flammable. (NTP, 1992)
Gesundheitsgefahren	ACUTE/CHRONIC HAZARDS: This compound is a lacrimator. When heated to decomposition it emits toxic fumes. (NTP, 1992)
Reaktive Gruppe	Halogenated Organic Compounds
Reactivity Alerts	Highly Flammable
Reactivity Profile	A halogenated epoxide. Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts. The chlorinated derivative has been shown to be incompatible with aniline, strong oxidizers, sulfuric acid, isopropylamine, zinc, aluminum, iron, etc. see epichlorohydrin.
Air and Water Reactions	Highly flammable. Water soluble.
Hazard Classes and Categories	Flam. Liq. 2 (100%)
Brandbekämpfung	Fires involving this material can be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Erste Hilfe	EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Anwendungen & Verwendung

Verwenden

Epifluorohydrin is used as a reagent in the synthesis of N-arylphosphoramidates. In addition, it is used in the synthesis of orally bioavailable ALK inhibitors in the treatment of tumors.