2-Aminopyridine

Nitrogen Compounds -> Pyridines

Flammable agents - 2nd degree

log Kow= 0.48

0.49

1.065 @ 20 °C/4 °C

1.07 @25 °C

White leaflets or large colorless crystals

WHITE POWDER OR CRYSTALS

White powder, leaflets, or crystals.

Leaflets, or large crystals

10 to 50 mg/mL at 66 °F (NTP, 1992)

Soluble in alcohol, benzene, ether, and hot petrol ether

>100 g/100 g water @ 20 °C

Soluble in ethanol, ethyl ether, and acetone

Water solubility: >100g/100mL at 20 °C

Solubility in water: very good

198 °F (NTP, 1992)

198 ° F

68 °C, 154 °F (closed cup)

68 °C c.c.

198 °F

154 °F

399 to 410 °F at 760 mmHg (NTP, 1992)

210.6 °C

Boiling point: 104-106 °C @ 20 mm Hg

211 °C

411 °F

210.6 °C @760 [mm Hg]

138 to 140 °F (NTP, 1992)

58.1 °C

58 °C

137 °F

58.1 °C

137 °F

This chemical does not meet GHS hazard criteria for 1.3% (2 of 156) of reports.

Danger

H301 (98.7%): Toxic if swallowed [Danger Acute toxicity, oral]

P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 156 reports by companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

Chemical: 2-Pyridinamine

Status: Active Update: 25-02-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/21500

2-Aminopyridine: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Poison

Poison

This chemical is combustible. (NTP, 1992)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

· Combustible material: may burn but does not ignite readily.

Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.

Excerpt from NIOSH Pocket Guide for 2-Aminopyridine:

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

· TOXIC and/or CORROSIVE; inhalation, ingestion or skin contact with material may cause severe injury or death.

A chemical plant worker died after a spill which contaminated his clothing. He did not remove his clothing, and symptoms began about 2 hours after the exposure with headache and dizziness followed by respiratory distress and convulsions. [ACGIH] See Pyridine.

2671 153

2671 153

Amines, Phosphines, and Pyridines

Amines, Phosphines, and Pyridines

2-AMINOPYRIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts with oxidizing agents (NTP, 1992).

AMINOPYRIDINES are amines. Highly toxic, may cause epilepsy-like convulsions, toxic effects resemble strychnine poisoning. When heated to decomposition (over 200 °C), it emits highly toxic fumes of oxides of nitrogen [Sax, 9th ed., p. 193].

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Use water spray, powder, alcohol-resistant foam, carbon dioxide.

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

General First Aid:

(General first aid procedures)

Extinguishant: Carbon dioxide, dry chemical, alcohol foam

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 45(SRC), determined from a structure estimation method(2), indicates that 2-aminopyridine is expected to have very high mobility in soil(SRC). The pKa of 2-aminopyridine is 6.86(9), indicating that this compound will partially exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts. Volatilization of 2-aminopyridine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.5X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(3). 2-Aminopyridine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 9.6X10-2 mm Hg(SRC), determined from a fragment constant method(4). 2-Aminopyridine degrades slowly(6) or is not readily biodegradable(5,8) in soil. In one study, 2-aminopyridine was found to completely degrade in 96 days under both aerobic and anaerobic conditions(7).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 45(SRC), determined from an estimation method(2), indicates that 2-aminopyridine is not expected to adsorb to suspended solids and sediment in water(SRC). The pKa of 2-aminopyridine is 6.86(8), indicating that this compound will partially exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts. Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.5X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), BCFs of 3.0-7.7 and <5.1-25 at a concentration of 0.1 and 0.01 mg/l(6), respectively, and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low.

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-aminopyridine, which has an estimated vapor pressure of 9.6X10-2 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-aminopyridine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 19 hrs(SRC), calculated from its rate constant of 2X10-11 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). Aminopyridines may be susceptible to photochemical degradation as this class of chemicals absorb above 280 nm(4).

AMINOPYRIDINES @ CONCN ABOVE 1X10-5 MOLAR CAUSED CONTRACTIONS OF GUINEA PIG ILEUM. AMINOPYRIDINES MAY ACT ON CHOLINERGIC NERVES IN ILEUM, CAUSING INCR RELEASE OF ACETYLCHOLINE BY FACILITATING CALCIUM MOVEMENT, NOT BLOCKING POTASSIUM CONDUCTANCE.

THE EFFECTS OF 2-, 3-, AND 4-AMINOPYRIDINES WERE INVESTIGATED ON THE ISOLATED CHICK NERVE-MUSCLE PREPARATION AND ON NERVE-FREE CELL CULTURES OF EMBRYONIC CHICK SKELETAL MUSCLE. ALL 3 COMPOUNDS REVERSED TUBOCURARINE BLOCKADE & AUGMENTED TWITCH HEIGHT IN INDIRECTLY STIMULATED ISOLATED NERVE-MUSCLE PREPN. THE AMINOPYRIDINES MAY FACILITATE NEUROMUSCULAR TRANSMISSION BY INCR ACETYLCHOLINE RELEASE IN RESPONSE TO NERVE STIMULATION.

2-AMINOPYRIDINE BLOCKED POTASSIUM CHANNELS OF SQUID AXON MEMBRANES IN MANNER DEPENDENT ON MEMBRANE POTENTIAL & DURATION & FREQUENCY OF VOLTAGE CLAMP PULSES. BINDING IS TO CLOSED K CHANNELS, RELEASED FROM OPEN CHANNELS IN VOLTAGE-DEPENDENT MANNER.

Rats were fed 100 or 1000 ppm methapyrilene in their diet for 1, 2, 4, 8 or 16 weeks. Liver microsomes were prepared from both control and treated rats. After incubation with 1 mM methapyrilene, eight metabolites were detected and six were quantitated. /One/ ... metabolites /was/ identified as ... 2-aminopyridine. ...

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.

It may enter the body through the skin.

PYRIDINE & ITS ALKYL DERIVATIVES ARE ABSORBED FROM GI TRACT, INTRAPERITONEAL CAVITY & LUNGS. PERITONEAL ABSORPTION IS APPARENTLY ONLY SLIGHTLY MORE RAPID & COMPLETE THAN GI ABSORPTION... IN GENERAL THE BASES ARE RAPIDLY ABSORBED THROUGH INTACT SKIN. /ALKYL DERIVATIVES OF PYRIDINE/

MAJORITY OF /PYRIDINE/ DERIVATIVES TESTED ... PENETRATE INTACT GUINEA PIG SKIN READILY. AMINOPYRIDINES, VINYLPYRIDINES & 4-PICOLINE PENETRATE SKIN MOST RAPIDLY & AMYL DERIV & 5-ETHYL-2-METHYLPYRIDINE ARE LEAST READILY ABSORBED. /AMINOPYRIDINES/

Used to manufacture drugs and dyes; [Merck Index # 473]

Intermediate in chemical synthesis

Intermediate for antihistamines and other pharmaceuticals

Chemical intermediate for manufacture of pharmaceuticals; use in the manufacture of dyes, lubricant antioxidants, and herbicides.

Synthetic Polymer MALDI Matrix Compounds

2-Pyridinamine: ACTIVE

DERIVATIVES OF 2-AMINOPYRIDINE ARE USED AS COUPLERS IN HAIR COLORING