Methallenestril

BREAST ENLARGEMENT & NODULARITY OCCURRED IN BOTH MALE & FEMALE CHILDREN AFTER CONSUMPTION OF VITAMIN CAPSULES CONTAMINATED WITH ESTROGENS. /ESTROGEN/

MALAISE, IRRITABILITY, & DEPRESSION...OCCUR WITH SMALL DOSES &...WITH LARGE DOSES. EFFECT ON LIBIDO IS ERRATIC, BEING INCR IN SOME & DECR IN OTHERS. ... CHANGES IN CONCN OF SOME OF CLOTTING FACTORS IN BLOOD...INCR INCIDENCE OF THROMBOPHLEBITIS & THROMBOEMBOLISM IN...SUPERFICIAL & DEEP VEINS. /ESTROGENS/

PULMONARY EMBOLISM, CEREBRAL EMBOLISM WITH STROKE & MESENTERIC VASCULAR OCCULSION OCCUR. CORONARY THROMBOSIS...INCR... ALTER HEPATIC FUNCTION, WHICH... ALTER...TESTS OF LIVER FUNCTION AS WELL AS VARIOUS SYNTHETIC & BIOTRANSFORMATION PROCESSES. ...DECR IN GLUCOSE TOLERANCE, & DIABETES MELLITUS MAY BE EXACERBATED. /ESTROGENS/

SERUM TRIGLYCERIDES RISE, &...HYPERLIPIDEMIA MAY OCCUR... COMPOSITION IS ALTERED...INCR OF GALL STONES... PORPHYRIA MAY BE PROVOKED. CHANGES IN CONCN OF BLOOD PROTEINS MAY OCCUR; THYROXINE- & GLUCOCORTICOID-BINDING PROTEINS ARE INCR, WHICH MAY ALTER ENDOCRINE RELATIONSHIPS. /ESTROGENS/

For more Human Toxicity Excerpts (Complete) data for METHALLENESTRIL (10 total), please visit the HSDB record page.

G - Genito urinary system and sex hormones

G - Genito urinary system and sex hormones

QG - Genito urinary system and sex hormones

QG - Genito urinary system and sex hormones

CONSIDERABLE PROGRESS HAS BEEN MADE IN ELUCIDATION OF MECHANISM OF ACTION OF ESTROGENS... PUTATIVE RECEPTOR PROTEINS FOR HORMONE HAVE BEEN DETECTED IN QUANTITY ONLY IN ESTROGEN-RESPONSIVE TISSUES... /ESTROGENS/

ESTROGENS ARE FIRST BOUND WITH VERY HIGH AFFINITY TO A CYTOPLASMIC 8 S RECEPTOR PROTEIN, WHICH THEN DISSOCIATES INTO A 4 S WITH ESTROGEN ATTACHED. ... THE ESTROGEN COMPLEX IS CONVERTED TO A 5 S SPECIES THAT IS TRANSPORTED TO THE NUCLEUS, WHERE ULTIMATE BINDING OF ESTROGEN-CONTAINING COMPLEX OCCURS. /ESTROGENS/

THE ACTIVITY OF...SYNTHETIC...ESTROGENS DEPENDS ON PRESENCE OF HYDROXYL GROUPS @ EXTREMITIES OF THEIR MOLECULES... HYDROXYLS...INVOLVED IN BINDING WITH SPECIFIC RECEPTOR PROTEINS, PRESENT IN CYTOSOL OF CELLS IN TARGET ORGANS. /ESTROGENS/

ESTROGENS USED IN THERAPY ARE...READILY ABSORBED THROUGH SKIN & MUCOUS MEMBRANES. WHEN THEY ARE APPLIED FOR LOCAL ACTION, ABSORPTION IS OFTEN SUFFICIENT TO CAUSE SYSTEMIC EFFECTS, & IN FACTORY WORKERS GYNECOMASTIA HAS FOLLOWED HANDLING OF DIETHYLSTILBESTROL WITHOUT GLOVES. /ESTROGENS/

URINARY EXCRETION RATE OF ESTROGENS IS QUITE SIMILAR WHETHER AGENTS ARE GIVEN ORALLY OR INTRAVENOUSLY, WHICH SUGGESTS THAT ABSORPTION OF MOST ESTROGENS FROM GI TRACT IS PROMPT & QUITE COMPLETE. /ESTROGENS/

NATURAL ESTROGENS ARE SOL IN WATER, &, WHEN INJECTED DISSOLVED IN OIL, ARE RAPIDLY ABSORBED & QUICKLY METABOLIZED. ... INACTIVATION OF ESTROGEN IN BODY IS CARRIED OUT MAINLY IN THE LIVER. /ESTROGENS/

CERTAIN PROPORTION OF ESTROGEN REACHING.../THE LIVER/ IS EXCRETED INTO THE BILE, ONLY TO BE REABSORBED FROM THE INTESTINE & CARRIED BACK AGAIN TO THE LIVER BY THE PORTAL VEIN. /ESTROGENS/