Cefotaxim-natrium

Cefotaxime Sodium

HCID 10695961CAS 64485-93-4
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Grundinformationen

Standard-SMILES
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(COC(C)=O)CS[C@H]12)c1csc(N)n1.[Na+]
InChIKey
AZZMGZXNTDTSME-JUZDKLSSSA-M
Summenformel
C16H16N5NaO7S2
Durchschnittliche Molmasse
477,5 g/mol
Monoisotopische Masse
477,03888413

Überblick

Cefotaxime sodium is a cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups. It contains a cefotaxime(1-).

Namen und Bezeichner

Bevorzugter Name
Cefotaxime Sodium
IUPAC
sodium (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Lokaler Name
Cefotaxim-natrium
Englischer Name
Cefotaxime sodium
Summenformel
C16H18N5NaO7S2
Molmasse
479.46

Namen und Synonyme

CEFOTAXIME SODIUMCEFOTAXIME SODIUM SALT64485-93-4Sodium cefotaximePretor(+)-Cefotaxime sodium saltHR 756DTXSID4046991RU 24756HR-756258J72S7TZHR756
Weitere Namen anzeigen
ctxCEFOTAXIME SODIUM STERILECLAFORANCEFOTAXIME NA-SALTCefotaxime free acidCEFOTAXIM SODIUM SALTCefotaxime Sodium (350 mg)Cefotaxime for peak identification
Ru-24756NSC-756666Sodium 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanateCHEBI:3498DTXCID201476109Cefotaxime and dextrose 2.4% in plastic containerCefotaxime and dextrose 3.9% in plastic containerCLAFORAN IN DEXTROSE 5% IN PLASTIC CONTAINER

Datenbank-Bezeichner

CAS
64485-93-4
PubChem CID
10695961
DTXSID
DTXSID4046991
ChEMBL
CHEMBL1010
ChEBI
CHEBI:3498
UNII
258J72S7TZ
EC Number
264-915-9

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
230 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
12
Frei drehbare Bindungen
8
Schwere Atome
31

Experimentelle und physikochemische Eigenschaften

Solubility68.2 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs · 2 Einträge

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Physikochemische Eigenschaften

Schmelzpunkt
162 · 162-163 C
Brechungsindex
61 ° · 61 ° (C=1, H2O)
storage temp.
2 · Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit
2 O: · H2O: aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.soluble
Aggregatzustand
powder
Farbe
white to yellow

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H317 (99.2%): May cause an allergic skin reaction [Warning Sensitization, Skin]

P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 132 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory InformationCefotaxime sodium: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Sens. 1 (99.2%)

Toxikologische Informationen

Drug Induced Liver Injury · 6 Einträge

Drug Induced Liver Injury Rank (DILIrank 2.0)

Cefotaxime sodium

vLess-DILI-concern

5

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

Sicherheitsdaten

wgk
2
hs_code
29419000
RTECS-Nr.
XI0250000
risk_code
42/43
hazard_code
Xn,Xi
safety_code
22-36/37-60-45-37-24

Chemie und Industrie

Pharmakologische Informationen

FDA Pharmacological Classification · 2 Einträge

CEFOTAXIME INJECTION

Cephalosporin Antibacterial [EPC]; Cephalosporins [CS]

MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Anwendungen · 2 Einträge

BeschreibungCefotaxime was synthesized by Hoechst and Roussel-Uclaf in 1977. It was the first derivative of cephalosporin to introduce the methoxyimino and aminothiazole groups at the 7 position of the cephem nucleus. Although it shows unexpectedly low oral absorption, its excellent activity against a wide range of gram-positive and gram-negative organisms, including Serratia, Enterobacter, Citrobacter, and anaerobes, guided research and development of the newer synthetic cephems, the so-called thirdgeneration cephalosporins.

VerwendenCefotaxime sodium salt acts as a beta-lactamase resistant antibiotic. It is used as an effective antibacterial against gram-negative bacteria, with the notable exception of pseudomonas and penicillin-resistant strains of streptococcus pneumoniae. It is used to treat infections of the bones, joints, skin, respiratory tract and blood stream.

Vor- und nachgelagerte Produkte

Nachgelagerte Produkte

Anbieter50 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海如吉生物科技发展有限公司+86-21-65211385-8001 36031160 · [email protected]
北京安司莫森技术有限公司010-82954736 13391601435 · [email protected]

Ergänzende Hinweise

DefinitionChEBI: A cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups.

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