Cefotaxim-natrium
Cefotaxime Sodium
Grundinformationen
- CAS
64485-93-4- Standard-SMILES
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(COC(C)=O)CS[C@H]12)c1csc(N)n1.[Na+]- InChIKey
AZZMGZXNTDTSME-JUZDKLSSSA-M- Summenformel
- C16H16N5NaO7S2
- Durchschnittliche Molmasse
- 477,5 g/mol
- Monoisotopische Masse
- 477,03888413
Überblick
Cefotaxime sodium is a cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups. It contains a cefotaxime(1-).
Namen und Bezeichner
- Bevorzugter Name
- Cefotaxime Sodium
- IUPAC
- sodium (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- Lokaler Name
- Cefotaxim-natrium
- Englischer Name
- Cefotaxime sodium
- Summenformel
- C16H18N5NaO7S2
- Molmasse
- 479.46
Namen und Synonyme
CEFOTAXIME SODIUMCEFOTAXIME SODIUM SALT64485-93-4Sodium cefotaximePretor(+)-Cefotaxime sodium saltHR 756DTXSID4046991RU 24756HR-756258J72S7TZHR756
Weitere Namen anzeigen
ctxCEFOTAXIME SODIUM STERILECLAFORANCEFOTAXIME NA-SALTCefotaxime free acidCEFOTAXIM SODIUM SALTCefotaxime Sodium (350 mg)Cefotaxime for peak identification
Ru-24756NSC-756666Sodium 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanateCHEBI:3498DTXCID201476109Cefotaxime and dextrose 2.4% in plastic containerCefotaxime and dextrose 3.9% in plastic containerCLAFORAN IN DEXTROSE 5% IN PLASTIC CONTAINER
Datenbank-Bezeichner
- CAS
64485-93-4- PubChem CID
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 230 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 12
- Frei drehbare Bindungen
- 8
- Schwere Atome
- 31
- Formalladung
- 0
- Komplexität
- 839
Experimentelle und physikochemische Eigenschaften
Solubility68.2 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 162 · 162-163 C
- Brechungsindex
- 61 ° · 61 ° (C=1, H2O)
- storage temp.
- 2 · Keep in dark place,Inert atmosphere,2-8°C
- Löslichkeit
- 2 O: · H2O: aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.soluble
- Aggregatzustand
- powder
- Farbe
- white to yellow
- PH
- pH(100g/l, 25℃) : 4.5～6.5
- Wasserlöslichkeit
- Soluble in water.
- Merck
- 14 · 14,1933
- BRN
- 5711411 · 5711411
- Stabilität
- Stable. Incompatible with strong oxidizing agents.
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H317 (99.2%): May cause an allergic skin reaction [Warning Sensitization, Skin]
P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 132 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory InformationCefotaxime sodium: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesSkin Sens. 1 (99.2%)
Toxikologische Informationen
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Cefotaxime sodium
vLess-DILI-concern
5
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
Sicherheitsdaten
- wgk
- 2
- hs_code
- 29419000
- RTECS-Nr.
- XI0250000
- risk_code
- 42/43
- hazard_code
- Xn,Xi
- safety_code
- 22-36/37-60-45-37-24
- Speicherklasse
Chemie und Industrie
Pharmakologische Informationen
FDA Pharmacological Classification
CEFOTAXIME INJECTION
Cephalosporin Antibacterial [EPC]; Cephalosporins [CS]
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Anwendungen
BeschreibungCefotaxime was synthesized by Hoechst and Roussel-Uclaf in 1977. It was the first derivative of cephalosporin to introduce the methoxyimino and aminothiazole groups at the 7 position of the cephem nucleus. Although it shows unexpectedly low oral absorption, its excellent activity against a wide range of gram-positive and gram-negative organisms, including Serratia, Enterobacter, Citrobacter, and anaerobes, guided research and development of the newer synthetic cephems, the so-called thirdgeneration cephalosporins.
VerwendenCefotaxime sodium salt acts as a beta-lactamase resistant antibiotic. It is used as an effective antibacterial against gram-negative bacteria, with the notable exception of pseudomonas and penicillin-resistant strains of streptococcus pneumoniae. It is used to treat infections of the bones, joints, skin, respiratory tract and blood stream.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Zugehörige Reaktionen
6
Notizen zur Verbindung
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