StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Verbindung

Magnesiumdistearat

Magnesium Stearate

HCID 11177
Neue NotizNeue ReaktionAnfrage stellen
Druckvorschau
GrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
TeilstruktursucheÄhnliche Strukturen suchen

Grundinformationen

CAS
557-04-0
Standard-SMILES
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
InChIKey
HQKMJHAJHXVSDF-UHFFFAOYSA-L
Summenformel
C36H70MgO4
Durchschnittliche Molmasse
591,2 g/mol
Monoisotopische Masse
590,5124524

Überblick

Magnesium distearate is an organic magnesium salt and a magnesium salt.

Namen und Bezeichner

Bevorzugter Name
Magnesium Stearate
IUPAC
magnesium bis(octadecanoate)
Lokaler Name
Magnesiumdistearat
Englischer Name
Magnesium stearate
Summenformel
C36H70MgO4
Molmasse
591.24

Namen und Synonyme

MAGNESIUM STEARATE557-04-0Magnesium distearateMagnesium octadecanoateDibasic magnesium stearateSynpro 90Octadecanoic acid, magnesium saltStearic acid, magnesium saltPetrac MG 20NFMagnesium stearate gMagnesii stearasSynpro Magnesium Stearate 90
Weitere Namen anzeigen
stearatedemagnesiumMagnesium Stearate BpMAGNESIUM STEARATE N.F.Magnesium Stearate Veg. NFC4d-ADolomolAnti-C4d-Apetracmg20nfnesium stearate
NP 1500SM 1000Octadecanoic acid, magnesium salt (2:1)CHEBI:925470097M6I30DTXSID2027208DAYCLINGRefChem:5973

Datenbank-Bezeichner

CAS
557-04-0
PubChem CID

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
80,3 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
4
Frei drehbare Bindungen
30
Schwere Atome
41
Formalladung
0
Komplexität
196

Experimentelle und physikochemische Eigenschaften

Chemical Classes · 2 Einträge

Other Classes -> Stearates

Other Classes -> Stearates

Cosmetics · 2 Einträge

Cosmetic ingredients (Magnesium Stearate) -> CIR (Cosmetic Ingredient Review)

Moisturising; Cosmetic colorant; Anticaking; Bulking

Odor · 2 Einträge

Odorless

Faint, characteristic odor

TasteTasteless
Food AdditivesANTICAKING AGENT OR FREE-FLOW AGENT, DRYING AGENT, FORMULATION AID, HUMECTANT -> FDA Substance added to food
Density · 2 Einträge

1.028

1.02 g/cm³

Color/Form · 3 Einträge

LUMPS

Fine, bulky, white powder

Soft, white, light powder

Solubility · 3 Einträge

IN 100 CC WATER: 0.003 G @ 15 °C; 0.004 G @ 25 °C; 0.008 G @ 50 °C

IN 100 CC SOLVENT @ 25 °C: 0.020 G IN ALCOHOL; 0.003 G IN ETHER

Solubility in water: none

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 6 Einträge

This chemical does not meet GHS hazard criteria for 54.9% (280 of 510) of all reports.

Warning

H315 (22.4%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 510 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

Gefahrenhinweise

Regulatory Information · 3 Einträge

Chemical: Octadecanoic acid, magnesium salt

Octadecanoic acid, magnesium salt (2:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Octadecanoic acid, magnesium salt (2:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Octadecanoic acid, magnesium salt: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Octadecanoic acid, magnesium salt: Human health tier I assessment
Fire HazardsCombustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.
Hazards Summary · 2 Einträge

This TLV Documentation applies only to stearic acid and magnesium, sodium, and zinc stearates. It excludes stearates of other metals. TLV Basis is lower respiratory tract irritation. No acute systemic effects of stearic acid have been reported after ingestion. . . . Sprague-Dawley rats fed stearic acid in their diet at 3000 ppm for 209 days showed 'severe pulmonary infection consisting of tracheobronchitis, lobular pneumonia, lipoid histiocytic response, and abscess formation.' [ACGIH] See Stearic acid.

Chemie und Industrie

Verwendung und Herstellung

Uses · 6 Einträge

CIR ingredient: Magnesium Stearate

Used in cosmetics, pharmaceuticals, food additives, waterproofing agents, plastic stabilizers, emulsifiers, and rubber lubricants and dusting agents; Stearic acid occurs naturally in human and animal fats and oils and in some vegetable oils, including cocoa oil. Stearic acid can be prepared from animal fat (triglyceride) by treating with water at high temperature, leading to hydrolysis of triglycerides, or by hydrogenation of unsaturated vegetable oils such as cottonseed oil. [ACGIH]

Used in baby dusting powders; as lubricant for plastics; as emulsifying agent in cosmetics; as drier in paints and varnishes; as flatting agent; as anticaking agent in foods and fire extinguishers; and as lubricant in making pharmaceutical tablets; [HSDB]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

IN BABY DUSTING POWDERS

Dusting powder, lubricant for plastics, emulsifying agent in cosmetics, drier in paints and varnishes and flatting agent.

Impuritiescontains small amounts of the oleate and 7% magnesium oxide. /technical grade/
U.S. Production · 4 Einträge

2023: 2,500,000 - <4,000,000 lb

(1972) 2.16X10+9 GRAMS

(1975) 1.79X10+9 GRAMS

(1984) 1.08X10+10 g

Consumer UsesFlame retardant
Industry UsesFlame retardant
Methods of ManufacturingREACTION OF SODIUM STEARATE WITH MAGNESIUM SULFATE
Formulations/Preparations · 3 Einträge

MAGNESIUM STEARATE /IS/ COMPD OF MAGNESIUM WITH MIXTURE OF SOLID ORG ACIDS OBTAINED FROM FATS, & CONSISTS CHIEFLY OF VARIABLE PROPORTIONS OF MAGNESIUM STEARATE & MAGNESIUM PALMITATE. IT CONTAINS EQUIVALENT OF 6.8-8.0% OF MAGNESIUM OXIDE (40.30).

GRADES: TECHNICAL, USP FCC.

A TYPICAL DRY COMPRESSED ANTIPERSPIRANT STICK/CONTAINS/0.25 wt% MAGNESIUM STEARATE

Zugehörige Reaktionen

19
Reaktionsaufzeichnung erstellen
Reaktionsgleichung von HRID 68194
HRID 68194als Eduktuspto-grants-2014_09
Reaktionsgleichung von HRID 68195
HRID 68195als Eduktuspto-grants-2014_09
Reaktionsgleichung von HRID 381198
HRID 381198als Eduktuspto-grants-2001_10
Reaktionsgleichung von HRID 408059
HRID 408059als Eduktuspto-grants-2014_06
Reaktionsgleichung von HRID 486322
HRID 486322als Produktuspto-grants-1994_03
Reaktionsgleichung von HRID 500290
HRID 500290als Eduktuspto-grants-2010_08
Reaktionsgleichung von HRID 642174
HRID 642174als Eduktuspto-grants-2010_04
Reaktionsgleichung von HRID 716609
HRID 716609als Eduktuspto-grants-2015_11
Seite 1 von 3

Notizen zur Verbindung

Wird geladen…

Auf dieser SeiteGrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
Weitere Aktionen
Neue NotizNeue ReaktionAnfrage stellen
11177
DTXSID
DTXSID2027208
ChEMBL
CHEMBL2106633
ChEBI
CHEBI:9254
UNII
70097M6I30
EC Number
209-150-3
Nikkaji
J43.178H
Animal Drugs
Pharmaceuticals -> UK Veterinary Medicines Directorate List
DecompositionWhen heated to decomposition it emits acrid smoke and toxic fumes.
Melting Point · 3 Einträge

88.5 °C (pure)

MP: 132 °C /Technical/

88 °C

Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Physikochemische Eigenschaften

Schmelzpunkt
200 °C · 200 °C (lit.)
Dichte
1.028 g/cm3 · 1.028g/cm3
storage temp.
Inert atmosphere,Room Temperature
Löslichkeit
alcohol: insoluble
Aggregatzustand
Fine Powder
Farbe
White
PH
7 · 7 (H2O) (slurry)
Geruch (Odor)
wh. soft oily powd., tasteless, odorless
Wasserlöslichkeit
Insoluble
Merck
14 · 14,5690
BRN
3919702 · 3919702
Stabilität
Stable. Incompatible with strong oxidizing agents.
Major Application
pharmaceutical (small molecule)
Kosmetik-Inhaltsstoffe Funktionen
MOISTURISINGANTICAKINGBULKINGCOLORANT
InChI
1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
InChIKey
DRJIJXNWSSRTTE-UHFFFAOYSA-M
SMILES
CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC
LogP
8.216 · 8.216 (est)
CAS Datenbank
557 · 557-04-0(CAS DataBase Reference)
EPA chemische Informationen
Magnesium stearate (557-04-0)

No listed effects of short-term or long-term exposure; [ICSC] Mildly toxic by ingestion; [HSDB] May cause irritation; [MSDSonline] See STEARATES.

FDA Requirements · 2 Einträge

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

An ingredient whose use in food or food packaging is subject to a prior sanction or approval within the meaning of section 201(s)(4) of the Act is exempt from classification as a food additive. ... Substances classified as stabilizers, when migrating from food-packaging material shall include: magnesium stearate.

EPA Safer ChemicalChemical: Magnesium stearate
FIFRA Requirements · 1 Eintrag

Residues of magnesium stearate are exempted from the requirement of a tolerance when used as a surfactant in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Chemical DangersDecomposes on burning. This produces irritating fumes.
Physical DangersDust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.
Other Hazardous ReactionsSpontaneously combustible.
Hazard Classes and Categories · 2 Einträge

Skin Irrit. 2 (22.4%)

Skin corrosion/irritation - Category 3

Sicherheit und Schutzausrüstung

Fire FightingIn case of fire in the surroundings, use appropriate extinguishing media.
First Aid Measures · 3 Einträge

Fresh air, rest.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Rest.

Disposal Methods · 1 Eintrag

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Spillage DisposalSweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.
Eye PreventionWear safety spectacles.
Fire PreventionNO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.
Inhalation RiskA nuisance-causing concentration of airborne particles can be reached quickly when dispersed.
Skin PreventionProtective gloves.
Exposure PreventionPREVENT DISPERSION OF DUST!
Allowable Tolerances · 1 Eintrag

Residues of magnesium stearate are exempted from the requirement of a tolerance when used as a surfactant in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Ingestion PreventionDo not eat, drink, or smoke during work. Wash hands before eating.
Inhalation PreventionUse local exhaust.

Toxikologische Informationen

Adverse Effects · 2 Einträge

ACGIH Carcinogen - Not Classifiable.

ACGIH Carcinogen - Not Classifiable.

Exposure RoutesThe substance can be absorbed into the body by inhalation.
Toxicity Summary · 2 Einträge

The CIR Expert Panel concluded that the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating and non-sensitizing, which may be based on a QRA...Magnesium Stearate

Safe for use in cosmetics, with qualifications

Signs and Symptoms · 2 Einträge

Cough.

Vomiting.

Human Toxicity Excerpts · 2 Einträge

/HUMAN EXPOSURE STUDIES/ ...DEATHS HAVE BEEN CAUSED BY ACCIDENTAL INHALATION OF THE /BABY DUSTING/ POWDER, /CONTAINING MAGNESIUM STEARATE/.

/HUMAN EXPOSURE STUDIES/ Slightly toxic by ingestion.

Non-Human Toxicity Excerpts · 1 Eintrag

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Magnesium stearate was fed to groups of 20 male and 20 female rats at levels of 0, 5, 10 and 20% in a semisynthetic diet for 3 months. Decreased weight gain was found in males in the 20% group. Urolithiasis was found in 8 males and in 7 females in the same group. Reduced relative liver weight was seen in males in the 10% and in the 20% groups, and an increased amount of iron was found in the livers of the 20% group. Nephrocalcinosis was reduced in females in the 20% group. In this experiment the no-effect-level is estimated to be 5% magnesium stearate in the diet, corresponding to 2,500 mg/kg bw/day.

Evidence for CarcinogenicityA4; Not classifiable as a human carcinogen. /Stearates; does not include stearates of toxic metals/

Regulatorische Informationen

FDA Requirements · 2 Einträge

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

An ingredient whose use in food or food packaging is subject to a prior sanction or approval within the meaning of section 201(s)(4) of the Act is exempt from classification as a food additive. ... Substances classified as stabilizers, when migrating from food-packaging material shall include: magnesium stearate.

FIFRA Requirements · 1 Eintrag

Residues of magnesium stearate are exempted from the requirement of a tolerance when used as a surfactant in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Sicherheitsdaten

wgk
-
tsca
TSCA listed
hs_code
29157030
RTECS-Nr.
WI4390000
risk_code
36/37/38
Toxizität
LD50 orally in Rabbit: > 2000 mg/kg
hazard_code
Xi
safety_code
26-37/39
Speicherklasse
11 - Combustible Solids
Giftige Stoffe Daten
557-04-0(Hazardous Substances Data)
Household Products
Information on 42 consumer products that contain Magnesium stearate in the following categories is provided:
Use Classification · 4 Einträge

EPA Safer Chemical Functional Use Classes -> Surfactants

Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern

Food Additives -> ANTICAKING_AGENT; EMULSIFIER; Food Additives -> -> JECFA Functional Classes

Cosmetics -> Moisturising; Cosmetic colorant; Anticaking; Bulking

General Manufacturing Information · 4 Einträge

Plastics Material and Resin Manufacturing

Octadecanoic acid, magnesium salt (2:1): ACTIVE

The more important dusting powders include ... magnesium stearate, NF ...

Microspheres containing the mucoadhesive polymer chitosan hydrochloride, with matrix polymer Eudragit RS, pipemidic acid as a model drug and agglomeration preventing agent magnesium stearate were prepared by the solvent evaporation method. The amount of magnesium stearate was varied and the following methods were used for microsphere evaluation: sieve analysis, drug content and dissolution determination, scanning electron microscopy, x-ray diffractometry, DSC and FTIR spectroscopy. The results showed that average particle size decreased with increasing amount of magnesium stearate used for microsphere preparation. This is probably a consequence of stabilization of the emulsion droplets with magnesium stearate. Higher pipemidic acid content in the microspheres was observed in larger particle size fractions and when higher amounts of magnesium stearate were used. It was also found that these two parameters significantly influenced the dissolution rate. The important reason for the differences in drug content in microspheres of different particle sizes is the diffusion of pipemidic acid from the acetone droplets in liquid paraffin during the preparation procedure. The physical state of pipemidic acid changed from crystalline to mostly amorphous with its incorporation in microspheres, as shown by x-ray diffractometry and differential scanning calorimetry. No differences were observed in the physical state of pipemidic acid and in microsphere shape and surface between different size fractions of microspheres, prepared with different amounts of magnesium stearate. Additionally, no correlation between the physical state of the drug in different microspheres and their biopharmaceutical properties was found.

Anwendungen · 2 Einträge

BeschreibungMagnesium stearate, also called octa decanoic acid, magnesium salt, is a white substance, powder which becomes solid at room temperature. It has the chemical formula Mg(C18H35O2)2. It is a salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Magnesium stearate melts at about 120 °C, is not soluble in water, and is generally considered safe for human consumption at levels below 2500 mg/kg per day.In 1979, the FDA's Subcommittee on GRAS (generally recognized as safe) Substances (SCOGS) reported, "There is no evidence in the available information on ... magnesium stearate ... that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current and in the manner now practiced, or which might reasonably be expected in the future.".

VerwendenMagnesium Stearate is the magnesium salt of stearic acid which functions as a lubricant, binder, emulsifier, and anticaking agent. it is a white powder that is insoluble in water. it is used as a lubricant or die release in tableting pressed candies and is also used in sugar- less gum and mints.

Darstellung

synthetischeMagnesium stearate is created by the reaction of sodium stearate with magnesium sulfate.

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

GlycerintristearatStearinsureFatty acid mixtureNatriumhydroxidMagnesiumoxidMagnesiumsulfatMagnesium sulfate heptahydrateMagnesiumchlorid

Nachgelagerte Produkte

(1R, 2S 3R, 6S)-1,2-Dimethyl-3,6-epoxycyclohexan-1,2-dicarbon-säureanhydridnaphtha steam reforming catalystsBILE SALTS

Ergänzende Hinweise

DefinitionMg(C18H35O2)2 or with one H2O. Technical grade contains small amounts of the oleate and 7% magnesium oxide, MgO.