PULCHINENOSIDE B4
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Grundinformationen
- CAS
129741-57-7- Standard-SMILES
C=C(C)[C@@H]1CC[C@]2(C(=O)O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O[C@@H]6OC[C@H](O)[C@H](O)[C@H]6O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)[C@@](C)(CO)[C@@H]5CC[C@]43C)[C@@H]12- Summenformel
- C59H96O26
- Durchschnittliche Molmasse
- 1.221,38 g/mol
Namen und Bezeichner
- Bevorzugter Name
- PULCHINENOSIDE B4
- Englischer Name
- PULCHINENOSIDE B4
- Summenformel
- C59H96O26
- Molmasse
- 1221.38
Namen und Synonyme
Anemoside B4Pulchinenoside CAnemoside B4 Pulchinenoside B4Chinensioside APULCHINENOSIDE B4Pulsatilla saponin B4Pulchinenoside B4 CRSAnemosideB4 129741-57-7Pulchinenoside C (Standard)Pulchinenoside C (Anemoside B4)
Datenbank-Bezeichner
- CAS
129741-57-7- PubChem CID
- 11636713
- ChEMBL
CHEMBL450226- UNII
- JP928BN4LE
- Nikkaji
- J1.608.006C
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 208 · 208-215℃
- Dichte
- 1.48 · 1.48
- Löslichkeit
- 125 mg/mL · DMSO : 125 mg/mL (102.34 mM; Need ultrasonic)
- Aggregatzustand
- Powder
- pka
- 12.5 · 12.50±0.70(Predicted)
- Farbe
- White to light yellow
- Major Application
- pharmaceutical
- InChIKey
- OUHBKBTZUPLIIA-UFEMLMIJNA-N
Chemie und Industrie
Anwendungen
BeschreibungPulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities. It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM. Pulchinenoside B4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner. Pulchinenoside B4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation.
VerwendenPulchinenoside C is a triterpenoid saponin extract which acts as a minor molluscicidal agent in addition to tumor necrosis factor-α secretion inhibition. Anti-inflammatory.
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上海如吉生物科技发展有限公司
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