HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
8-Methylchinolin
Quinoline, 8-Methyl- · 8-methyquinoline · 8-Methyl · 0-Toluquinoline · O-TOLUQUINOLINE · 8-Methylchinolin · 8-METHYLQUINOLINE · 8-methyl-quinolin
Identifikatoren & physikalische Daten
| CAS No. | 611-32-5 |
|---|---|
| Summenformel | C10H9N |
| Durchschnittliche Molmasse | 143,18 g/mol |
| Monoisotopische Masse | 143,07349929 g/mol |
| SMILES | Cc1cccc2cccnc12 |
| InChIKey | JRLTTZUODKEYDH-UHFFFAOYSA-N |
| PubChem CID | 11910 |
| ChEMBL | CHEMBL1702610 |
| ChEBI | CHEBI:48984 |
| EC No. | 210-264-0 |
| DTXSID | DTXSID8020888 |
| Lokaler Name | 8-Methylchinolin |
Chemische & physikalische Eigenschaften
| XLogP | 2,6 |
|---|---|
| Polarare Oberfläche (TPSA) | 12,9 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 11 |
| Formalladung | 0 |
| Komplexität | 133 |
| SpringerMaterials Properties | Boiling point |
| LogP (Verteilungskoeffizient) | 2.6 |
| Dichte | 1.0719 at 68 °F (NTP, 1992) - Denser than waterwill sink1.052 g/mL at 25 °C(lit.) |
| Löslichkeit | 1 to 5 mg/mL at 63 °F (NTP, 1992)Chloroform, Methanol0.1-0.5 g/100 mL at 17 ºC |
| Flammpunkt | 221 °F (NTP, 1992) |
| Siedepunkt | 478 °F at 751 mmHg (NTP, 1992)245 °C |
| Schmelzpunkt | -112 °F (NTP, 1992)-80 °C |
| Dampfdruck | 5.9 mmHg at 75 °F8.0 mmHg at 111 °F12.6 mmHg at 149 °F (NTP, 1992) |
| Physical Description | 8-methylquinoline appears as yellow liquid or oil. (NTP, 1992) |
| Brechungsindex | n20/D 1.614(lit.) |
| Lagerbedingungen | Room Temperature |
| pKa (Säurekonstante) | 5.03±0.17(Predicted) |
| Aggregatzustand | Liquid |
| Farbe | Clear yellow |
| Wichte | 1.052 |
| BRN | 111340 |
| InChI | 1S/C10H9N/c1-8-4-2-5-9-6-3-7-11-10(8)9/h2-7H,1H3 |
| InChIKey | JRLTTZUODKEYDH-UHFFFAOYSA-N |
| SMILES | Cc1cccc2cccnc12 |
| CAS Datenbank | 611-32-5(CAS DataBase Reference) |
| NIST chemische Informationen | Quinoline, 8-methyl-(611-32-5) |
| EPA chemische Informationen | 8-Methylquinoline (611-32-5) |
Sicherheit & Vorschriften
| GHS-Einstufung | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P203, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 47 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: Quinoline, 8-methyl-Quinoline, 8-methyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Quinoline, 8-methyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711) |
| Brandgefahren | This chemical is combustible. (NTP, 1992) |
| Gesundheitsgefahren | SYMPTOMS: This compound may be absorbed through the skin and it causes skin irritation. The vapor or mist is irritating to the eyes, mucous membranes and upper respiratory tract. |
| Reaktive Gruppe | Amines, Phosphines, and Pyridines |
| Reactivity Profile | 8-METHYLQUINOLINE may be sensitive to exposure to light. May react vigorously with strong oxidizing agents and strong acids (NTP, 1992). Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. |
| Air and Water Reactions | Slightly soluble in water. |
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| Brandbekämpfung | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Personal Protective Equipment (PPE) | RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992) |
| Wassergefährdungsklasse (WGK) | 3 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 29334900 |
| RTECS-Nr. | VC0562000 |
| R-Sätze (R) | 36/37/38-68-22 |
| Gefahrensymbole | Xi,Xn |
| Sicherheitshinweise (S) | 26-36-45-36/37/39 |
| Gefahrenklasse | IRRITANTEye Irrit. 2Skin Irrit. 2STOT SE 3 |
| Lagerklasse | 10 - Combustible liquids |
Anwendungen & Verwendung
Verwenden
8-Methylquinoline has been used in preparation of osmium chloridophosphine complexes, as quinoline carbene tautomers.Tumorigenic potential of 8-methylquinoline has been evaluated in newborn CD-1 mice and Sprague-Dawley rats.