2-Phenylpropan-2-ol

0.9735 @ 20 °C/4 °C

0.9735 @ 20°C

The /process/ of corrosion was studied at several points along the flow in a biological treatment facility for phenolic waters. The waters contained phenol, sulfate, isopropylbenzene hydroperoxide, butylphenol, dimethylphenylcarbinol and other organic substances. Sulfate has been reduced by the action of Desulfovibrio desulfuricans. The rate of corrosion was assessed quantitatively using gravimetric and penetration indices, qualitatively by macroscopic observation. The rate of corrosion on carbon steel ranged from 0.04 to 0.8 g/sq m/hr where local forms of corrosion were detected. ...

202 °C @ 760 MM HG

202 °C @760 [mm Hg]

Vapor pressure = 0.52 mm Hg at 37.8 °C

0.52 [mm Hg] @37 °C

CBI; Liquid

Solid; [HSDB] Yellow liquid; mp = 32-34 deg C; [MSDSonline]

This chemical does not meet GHS hazard criteria for 1.2% (24 of 1959) of reports.

Warning

H302 (98.8%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1959 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

Chemical: Benzenemethanol, .alpha.,.alpha.-dimethyl-

Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)

Benzenemethanol, .alpha.,.alpha.-dimethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzenemethanol, .alpha.,.alpha.-dimethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 30-04-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/10103

2-Phenyl-2-propanol: Does not have an individual approval but may be used under an appropriate group standard

Higher alcohols are not highly toxic in the industrial setting; Can cause liver injury, somnolence, and respiratory depression in experimental animals; [HSDB] Caused somnolence and changes in liver enzymes in inhalation study of rats; [RTECS] An irritant; [MSDSonline]

Acute Tox. 4 (98.8%)

Acute toxicity (Oral) - Category 4

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

3.1 [mg/m3]

34 [mg/m3]

210 [mg/m3]

TERRESTRIAL FATE: Based on a recommended classification scheme(1), estimated Koc values of 36 to 270(SRC), determined from a structure estimation method(2), and an estimated log Kow(3,SRC) with a recommended regression-derived equation(5), indicate that 2-phenylisopropanol will have medium to very high mobility in soil(SRC). Volatilization of 2-phenylisopropanol may not be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 3.8X10-7 atm-cu m/mole(4,SRC), but may be important from dry soil surfaces(SRC) based on an estimated vapor pressure of 0.047 mm Hg at 25 °C(5,SRC) and a measured vapor pressure of 0.52 mm Hg at 37.8 °C(7). According to a Zahn-Wellens test, 2-phenylisopropanol will biodegrade readily in soil(6).

AQUATIC FATE: Based on a recommended classification scheme(1), estimated Koc values of 36 to 270(SRC), determined from a structure estimation method(2), and an estimated log Kow(3,SRC) with a recommended regression-derived equation(5), indicate that 2-phenylisopropanol has the potential to adsorb to suspended solids and sediment(SRC) in the water. 2-Phenylisopropanol should not volatilize from water surfaces based on an estimated Henry's Law constant of 3.8X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). An estimated BCF value of 18(4,SRC), from an estimated log Kow(3,SRC), suggests that 2-phenylisopropanol will not bioconcentrate in aquatic organisms(SRC) according to a recommended classification scheme(6). According to a Zahn-Wellens test, 2-phenylisopropanol will biodegrade readily in water(7). 2-Phenylisopropanol may undergo reaction with photochemically produced hydroxyl radicals in water(8) with a half-life of approximately 170 days(8,9,SRC).

ATMOSPHERIC FATE: According to a suggested classification scheme(1), an estimated vapor pressure of 0.047 mm Hg at 25 °C(2,SRC) indicates that 2-phenylisopropanol will exist in the vapor phase in the ambient atmosphere. Vapor-phase 2-phenylisopropanol is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 3 days(3,SRC).

2-Phenylisopropanol has been detected in wastewater from the organics and plastics (23 ng/ul extract) and transportation equipment (2513 ng/ul extract) industries(1). At the Northeast Sewage Treatment plant located on the Delaware River near Philadelphia, 2-phenylisopropanol was detected at 70 ppb in the inflow, at 70 ppb in the outflow, at 2 ppb 2 miles upstream, and at 0.5 ppb one mile downstream(2). 2-Phenylisopropanol has been qualitatively identified in advanced waste treatment water from Orange County, CA(3).

Using a structure estimation method based on molecular connectivity indexes(1), the Koc for 2-phenylisopropanol can be estimated to be about 36(SRC). The Koc of 2-phenylisopropanol can also be estimated to be approximately 274(SRC), using an estimated log Kow of 1.95(2,SRC) and a regression-derived equation(3,SRC). According to a recommended classification scheme(4), these estimated Koc values suggest that 2-phenylisopropanol has very high to medium mobility in soil(SRC).

2-Phenyl-2-propanol (CAS # 617-94-7) was evaluated for acute oral toxicity. The LD50 was determined to range from 1,400 to 3,000 mg/kg. No further information was submitted.

2-Phenyl-2-propanol (CAS # 617-94-7) was evaluated for dermal sensitization. Fifty-five human subjects received 24 hour exposures to test patches 3 times a week for 3 weeks and a challenge patch in the 6th week. There was little or no primary irritation. There was an indication of skin sensitization in 7 of the 55 subjects, and equivocal evidence of sensitization in 10 other subjects.

2-Phenyl-2-propanol (CAS # 617-94-7) was evaluated for primary dermal irritation. Daily application of the test substance to the skin of guinea pigs produced mild primary irritation. No further information was submitted.

2-Phenyl-2-propanol (CAS # 617-94-7) was evaluated for primary dermal irritation. Daily application of the test substance to the skin of rabbits produced mild primary irritation. No further information was submitted.

For more TSCA Test Submissions (Complete) data for 2-PHENYLISOPROPANOL (6 total), please visit the HSDB record page.

Using the Zahn-Wellens test, 2-phenylisopropanol biodegraded completely in 9 days(1).

Nine strains of non-pathogenic gram negative soil bacteria able to degrade dimethylphenylcarbinol ... a component of the wastes from phenol production, were selected. The dynamics of degradation of this substrate and changes in the UV spectra of the growth medium typical of all the strains obtained are described for the strain Pseudomonas putida GFS-106. This strain, which is also able to degrade phenol, was successfully used for the purification of phenolic wastes. It is shown that the culture liquid after complete dimethylphenylcarbinol by strains cultivated on a mineral medium is less toxic for some microorganisms than the initial soln of this cmpd.

An estimated BCF value of 18 was calculated for 2-phenylisopropanol(SRC), using an estimated log Kow of 1.95(1,SRC) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms will not be an important fate process(SRC).

The Henry's Law constant for 2-phenylisopropanol is estimated as 3.8X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that 2-phenylisopropanol will be essentially nonvolatile from water surfaces(2,SRC). 2-Phenylisopropanol's vapor pressure, 0.047 mm Hg(3,SRC) indicates that volatilization from dry soil surfaces may occur. However, 2-phenylisopropanol's Henry's Law constant(1,SRC) indicates that volatilization from moist soil may not occur(SRC).

THE ORAL LD50 VALUE OF DIMETHYLPHENYLCARBINOL WAS 1.950 G/KG IN MICE AND 2.250 G/KG IN RATS. THE CLINICAL TOXIC SYMPTOMS WERE SIMILAR TO THOSE OF CNS DEPRESSANTS. DERMATITIS WAS INDUCED IN GUINEA PIGS, AS WERE OCULAR BURNS IN RABBITS.

THE SENSITIVITY OF RATS AND MICE TO DIMETHYLPHENYLCARBINOL (I) WAS PRACTICALLY SIMILAR. I AFFECTED THE NERVOUS SYSTEM, LIVER, AND KIDNEYS. UNDER ACUTE INHALATION, I CAUSES A STEADY DECREASE IN THE PEROXIDASE ACTIVITY AND INCREASE IN THE BLOOD CHOLINESTERASE IN RATS. CHRONIC I INCREASED THE NUMBER OF LEUKOCYTES SUBSTANTIALLY, REDUCED HEMOGLOBIN CONTENT OF THE BLOOD, AND INCREASED THE ACTIVITY OF AMINOTRANSFERASE.

Eye irritation score of 5 /From table/

Skin irritation score of 3 /From table/

Maximum inhalation exposure of saturated vapor with no mortality = 8 hours /From table/

The rate constant for the vapor-phase reaction of 2-phenylisopropanol with photochemically produced hydroxyl radicals has been estimated as 5.5X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 3 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). The rate constant for the reaction between photochemically produced hydroxyl radicals in water and 2-phenylisopropanol is 4.6X10+9 L/mole-sec(2); assuming that the concentration of hydroxyl radicals in brightly sunlit natural water is 1X10-17 M(3), the half-life would be about 174 days(SRC).

DIMETHYLPHENYLCARBINOL IS A METABOLITE OF ISOPROPYLBENZENE.

The enantioselective metabolism of cumene was studied in rabbits. The major metabolites identified /in urine/ were 2-phenyl-2-propanol, (R)-(+)-2-phenyl-1-propanol, (S)-(+)-2-phenylpropanoic acid and (R)-(-)-2-hydroxy-2-phenylpropanoic acid. Based on these metabolites, two routes of cumene metabolism were /noted/.

Used as a solvent, chemical intermediate, and flotation frother; [HSDB]

Metal Extraction and Refining [Category: Industry]

SOLVENT; CHEM INT

As a flotation frother.

All Other Basic Organic Chemical Manufacturing

Benzenemethanol, .alpha.,.alpha.-dimethyl-: ACTIVE