Cyclohexylacetat

2.640

2.64 (calculated)

0.966 (USCG, 1999) - Less dense than water; will float

0.968 g/cu cm at 20 °C

Density (at 20 °C): 0.97 g/cm³

Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.02

0.971-0.978

This chemical does not meet GHS hazard criteria for 2.1% (39 of 1843) of reports.

Warning

H226 (97.8%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1843 reports by companies from 5 notifications to the ECHA C&L Inventory.

Warning

Chemical: Acetic acid, cyclohexyl ester

Regulation (EC) No 1831/2003 (amended)

Acetic acid, cyclohexyl ester: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Special Hazards of Combustion Products: Emits toxic fumes under fire conditions. Vapor may travel considerable distance to a source of ignition and flash back. (USCG, 1999)

· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Flammable. Above 58 °C explosive vapour/air mixtures may be formed.

May be harmful by inhalation, ingestion, or skin absorption. Causes eye and skin irritation. (USCG, 1999)

· May cause toxic effects if inhaled or absorbed through skin.

Narcotic; [Hawley] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations may cause CNS effects; Defats the skin; [ICSC] A skin and eye irritant; [CAMEO] A moderate skin, eye, nose, and throat irritant; Inhalation of high concentrations can cause CNS depression; [CHEMINFO] Safe when used as a flavoring agent; [JECFA] An irritant; [MSDSonline] See ORGANIC SOLVENTS.

Cyclohexyl acetate is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) when intended for use in or on food it is of appropriate food grade and is prepared and handled as a food ingredient. Synthetic flavoring substances and adjuvants incl benzyl acetate may be safely used in foods.

CYCLOHEXANOL ACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:

Use dry powder, alcohol-resistant foam, carbon dioxide, water spray. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Rest. Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

INHALATION: Call for medical aid. Remove the victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

General First Aid:

/USE/ FOAM, CARBON DIOXIDE, DRY CHEM...

Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources. Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.

IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS...SHOULD BE STORED IN COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD & SHOULD BE PERIODICALLY INSPECTED & MONITORED.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

If material not on fire and not involved in fire: keep sparks, flames, and other sources of ignition away; keep material out of water sources and sewers; build dikes to contain flow as necessary; attempt to stop leak if without undue personnel hazard; use water spray to knock-down vapors.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 650(SRC), determined from an estimated log Kow(2,SRC) and a regression-derived equation(3), indicates that cyclohexyl acetate is expected to have low mobility in soil(SRC). Volatilization of cyclohexyl acetate from moist soil surfaces is expected to be important(SRC) given an estimated Henry's Law constant of 1.2X10-4 atm-cu m/mole(SRC), using a fragment constant estimation method(4). The potential for volatilization of cyclohexyl acetate from dry soil surfaces may exist(SRC) based on a vapor pressure of 11 mm Hg(5). Volatilization from soil surfaces is expected to be attenuated by adsorption to organic matter(SRC). In general, acetates are expected to be readily biodegradable(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 650(SRC), determined from an estimated log Kow of 2.64(2,SRC) and a regression-derived equation(3), indicates that cyclohexyl acetate is expected to adsorb to suspended solids and sediment in water(SRC). Cyclohexyl acetate is expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 1.2X10-4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated volatilization half-lives for a model river and model lake are 12 hours and 7.4 days, respectively(3,SRC). Adsorption to suspended solids and sediment in the water column is expected to attenuate this process(SRC). The volatilization half-life from a model pond 2 m deep is estimated to be about 5.7 days ignoring adsorption(5); when considering maximum adsorption, the volatilization half-life increases to 17 days(5). According to a classification scheme(6), an estimated BCF of 22(3,SRC), from an estimated log Kow(2,SRC), suggests the potential for bioconcentration in aquatic organisms is low(SRC). In general, acetates are expected to be readily biodegradable(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cyclohexyl acetate, which has a vapor pressure of 11 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase cyclohexyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.4 days(3,SRC).

Cough. Sore throat.

Dry skin. Redness.

Redness. Pain.

Drowsiness. Unconsciousness. Further see Inhalation.

The Koc of cyclohexyl acetate is estimated as 650(SRC), using an estimated log Kow of 2.64(1,SRC) and a regression-derived equation(2,SRC). According to a classification scheme(3), this estimated Koc value suggests that cyclohexyl acetate is expected to have low mobility in soil(SRC).

EXPOSURE TO 516 PPM...CAUSED SOME IRRITATION OF PHARYNX, LARYNX & CONJUNCTIVA & AS THE ONLY AFTER-EFFECT, A SWEETISH TASTE.

Inhalation exposure of two men to 3 mg/l cyclohexyl acetate for 45 min produced eye and throat irritation, which disappeared soon after exposure ended.

An estimated BCF of 22 was calculated for cyclohexyl acetate(SRC), using an estimated log Kow of 2.64(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for cyclohexyl acetate is estimated as 1.2X10-4 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that cyclohexyl acetate is expected to volatilize from water surfaces(2,SRC). Based on this Henry's Law constant, the estimated volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 12 hours(2,SRC). The estimated volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 7.4 days(2,SRC). The volatilization half-life from a model pond 2 m deep is estimated to be about 5.7 days ignoring adsorption(3); when considering maximum adsorption, the volatilization half-life increases to 17 days(3). Cyclohexyl acetate's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of cyclohexyl acetate from dry soil surfaces may exist(SRC) based on a vapor pressure of 11 mm Hg(3).

Rabbits exposed to a concn of 700 ppm (4.0 mg/l) cyclohexyl acetate in for 4.8 hr resulted in irritation to nose and eyes, recovery. Exposures to 1700 ppm (10 mg/l) cyclohexyl acetate in for 4.8 hrs resulted in lethal. Cats exposed to 1700 ppm (10 mg/l) cyclohexyl acetate in for 10 hr resulted in deep /SRP: CNS depression and death/. /From table/

...1020-1630 PPM FOR 5 CONSECUTIVE DAYS CAUSED MODERATE IRRITATION OF MUCOUS MEMBRANES, FATIGUE & DROWSINESS BUT WITH COMPLETE RECOVERY /IN CATS & DOGS/.

...ANIMALS ACUTELY INTOXICATED...SHOWED SEVERE IRRITATION OF RESP TRACT & CONGESTION OF LIVER & KIDNEYS...

SYMPTOMS OF INTOXICATION /WERE/ IRRITATION OF EYES & NOSE, RESTLESSNESS, TREMORS, CONVULSIONS, INCOORDINATION FOLLOWED BY /SRP: CNS DEPRESSION/, IF DEEP USUALLY FATAL. IN MICE, SC INJECTION WAS FOLLOWED BY DYSPNEA & PARALYSIS...CHANGES IN THE ORGANISM /WERE/ TRACHEITIS, BRONCHITIS, EDEMA OF LUNGS, HYPEREMIA OF LIVER & KIDNEYS.

For more Non-Human Toxicity Excerpts (Complete) data for CYCLOHEXYL ACETATE (6 total), please visit the HSDB record page.

Cyclohexyl acetate is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) when intended for use in or on food it is of appropriate food grade and is prepared and handled as a food ingredient. Synthetic flavoring substances and adjuvants incl benzyl acetate may be safely used in foods.

Used as solvent for cellulose ethers, nitrocellulose, basic dyes, blown oils, raw rubber, metallic soaps, driers, shellac, lacquers, bitumens, and resins; Also used as a synthetic flavor; [HSDB] Used as fragrance ingredient; in the preparation of lacquers for collodion cotton; as a substitute for amyl acetate in textile production; for improving adhesion of leather varnishes; in the waterproofing industry; [CHEMINFO]

Textiles (Fiber & Fabric Manufacturing) [Category: Industry]

SYNTHETIC FLAVOR FOR FOOD

AS A SOLVENT

Good solvent for cellulose ethers and nitrocellulose and has powerful solvency for basic dyes, blown oils, raw rubber, metallic soaps, driers, shellac, bitumens, and a wide range of natural and synthetic resins and gums. Used in spraying and brushing lacquers imparting blush resistance and good flow.

BY DIRECT ESTERIFICATION OF CYCLOHEXANOL: DURRANS, TH (1950) SOLVENTS, 6TH ED CHAPMAN & HALL, LONDON.

BY HEATING CORRESPONDING ALCOHOL WITH ACETIC ANHYDRIDE OR ACETIC ACID IN PRESENCE OF TRACES OF SULFURIC ACID. /FROM TABLE/

Fragrance Ingredients

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Acetic acid, cyclohexyl ester: ACTIVE

A POWERFUL SOLVENT FOR CELLULOSE NITRATE, OTHER CELLULOSE ESTERS & MANY RESINS, & GUMS & COLLODION COTTON. .../USED/ IN TEXTILE INDUST, AS SUBSTITUTE FOR AMYL ACETATE...IN LEATHER INDUST, FOR IMPROVING ADHESION OF LEATHER VARNISHES.../&/ IN WATERPROOFING INDUST.

FEMA NUMBER 2349. 20 PPM IN NON-ALCOHOLIC BEVERAGES; 15 PPM IN ICE CREAM, ICES, ETC; 100 PPM IN CANDY; 110 PPM IN BAKED GOODS. /FROM TABLE/