Magnesium Acetate Tetrahydrate

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

This chemical does not meet GHS hazard criteria for 100% (90 of 90) of all reports.

Not Classified

Aggregated GHS information provided per 90 reports by companies from 2 notifications to the ECHA C&L Inventory.

Not Classified

Chemical: Acetic acid, magnesium salt, tetrahydrate

Acetic acid, magnesium salt, hydrate (2:1:4) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, magnesium salt, hydrate (2:1:4) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Magnesium acetate, tetrahydrate: Non hazardous

Not Classified

Not Classified

46 [mg/m3]

490 [mg/m3]

3000 [mg/m3]

Magnesium is an essential cofactor for many enzymatic reactions such as protein synthesis and ATP production. It also participates in adenylyl cyclase pathway and tyrosine kinase signalling pathways. Magnesium may also play a role in regulating glucose metabolism. It serves as an essential cation for a number of biochemical processes involved in nerve signaling, bone mineralization and muscle contractions.

Magnesium is an essential element that regulates vascular function and blood pressure. Magnesium ions electrostatically stabilize the adenylyl cyclase complex and enhance its catalytic actions and production of cAMP. They also regulate the level of phosphorylation in various pathways by the formation of a transition state of phosphoryl transfer reaction by protein kinases and stabilize ATP binding to protein kinases via electrostatic interactions. Many metabolic enzymes involved in glycolysis and Krebs cycle are magnesium-dependent. Studies show that magnesium ions decrease blood pressure and that magnesium deficiency is often associated with vasoconstriction and increased blood pressure. Magnesium ions also regulate other ions entering and exiting the cell membrane by acting as a ligand in N-methyl-D-aspartate receptor. Magnesium-containing laxatives cause diarrhea through water retention and increased fecal mass, which stimulates peristalsis. When used as an electrolyte supplement, magnesium acetate tetrahydrate induces diuresis and a metabolic alkalinizing effect.

MAGNESIA ACETICA

Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Activity [MoA]; Calculi Dissolution Agent [EPC]; Increased Large Intestinal Motility [PE]; Stimulation Large Intestine Fluid/Electrolyte Secretion [PE]; Inhibition Small Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Laxative [EPC]; Magnesium Ion Exchange Activity [MoA]

Intestinal absorption is achieved mainly through passive diffusion.

Mainly renal exctretion, where up to 97% of magnesium may be excreted renally during hypermagnesemia.

Magnesium ions display approximate volume of distribution of 0.2 to 0.4 L/kg

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern