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N,N-Dimethylpyridin-4-amin
DMAP · N,N-Dimethylpyridin-4-amine · N,N-Dimethyl-4-aminopyridine · p-Dimethylaminopyridine · 4,4-dimethylaminopyridine · 4-(Dimethylamino)pyridine, 99%, prilled · 4-(N,N-dimethlyamino)pyridine · 26DCLPY
Identifikatoren & physikalische Daten
| CAS No. | 1122-58-3 |
|---|---|
| Summenformel | C7H10N2 |
| Durchschnittliche Molmasse | 122,17 g/mol |
| Monoisotopische Masse | 122,08439833 g/mol |
| SMILES | CN(C)c1ccncc1 |
| InChIKey | VHYFNPMBLIVWCW-UHFFFAOYSA-N |
| PubChem CID | 14284 |
| ChEMBL | CHEMBL3561645 |
| ChEBI | CHEBI:182593 |
| EC No. | 214-353-5 |
| DTXSID | DTXSID0044369 |
| Lokaler Name | N,N-Dimethylpyridin-4-amin |
Chemische & physikalische Eigenschaften
| XLogP | 1,3 |
|---|---|
| Polarare Oberfläche (TPSA) | 16,1 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 2 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 9 |
| Formalladung | 0 |
| Komplexität | 75 |
| Dampfdruck | 1.0 [mmHg]0.169 hPa at 20 °C |
| Physical Description | Large CrystalsColorless solid[Merck Index] Beige crystalline solid[Sigma-Aldrich MSDS] |
| Collision Cross Section | 120.6 Ų [M+H]+ [CCS Type: DTBuffer gas: N2Ionization: APCI+Dataset: TOXCASTSource Identifier: DTXSID0044369]120.5 Ų [M+H]+ [CCS Type: DTIonization: ESI+ |
| Schmelzpunkt | 112 °C |
| Siedepunkt | 162 °C |
| Dichte | 0.906 g/mL at 25 °C |
| Brechungsindex | n20/D 1.431 |
| Flammpunkt | 110 °C |
| Lagerbedingungen | Store below +30°C. |
| Löslichkeit | methanol: 50 mg/mL, clear76 g/L (25 ºC) |
| Aggregatzustand | prilled |
| pKa (Säurekonstante) | pKa (20°): 9.7 |
| Farbe | off-white to yellow |
| pH | 11 (60g/l, H2O, 20℃) |
| Geruch | characteristic odor |
| Merck | 14,3389 |
| BRN | 110354 |
| Stabilität | Stable. Incompatible with acids, oxidizing agents. |
| InChI | 1S/C7H10N2/c1-9(2)7-3-5-8-6-4-7/h3-6H,1-2H3 |
| InChIKey | VHYFNPMBLIVWCW-UHFFFAOYSA-N |
| SMILES | CN(C)c1ccncc1 |
| LogP (Verteilungskoeffizient) | 1.34 at 25℃ |
| CAS Datenbank | 1122-58-3(CAS DataBase Reference) |
| NIST chemische Informationen | 4-Pyridinamine, N,N-dimethyl-(1122-58-3) |
| EPA chemische Informationen | 4-(Dimethylamino)pyridine (1122-58-3) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 1.1% (6 of 522) of reports.DangerH301 (98.9%): Toxic if swallowed [Danger Acute toxicity, oral]H310 (70.3%): Fatal in contact with skin [Danger Acute toxicity, dermal]H314 (32.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H315 (59.4%): Causes skin irritation [Warning Skin corrosion/irritation]H318 (32.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]H319 (49.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H331 (36%): Toxic if inhaled [Danger Acute toxicity, inhalation]H335 (37.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]H370 (17%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]H411 (36%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P308+P316, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 522 reports by companies from 53 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 6 of 522 reports by companies.There are 52 notifications provided by 516 of 522 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Chemical: 4-Pyridinamine, N,N-dimethyl-4-Pyridinamine, N,N-dimethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 4-Pyridinamine, N,N-dimethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711) |
Anwendungen & Verwendung
Verwenden
4-Dimethylaminopyridine (Valaciclovir EP Impurity G; Valacyclovir USP Related Compound G) is a highly efficient catalyst for acylation reactions.