3-Methyl-2-pent-2-enylcyclopent-2-enon

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.; Environmental precautions: Do not let product enter drains.; Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Normal measures for preventive fire protection.

Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Eye/face protection: Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection: Handle with gloves.

Body Protection: Impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 295(SRC), determined from a structure estimation method(2), indicates that jasmone is expected to have moderate mobility in soil(SRC). Volatilization of jasmone from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.2X10-5 atm-cu m/mole(SRC), using a fragment constant estimation method(2). Even though the vapor pressure is low environmentally at standard temperature and pressure, 0.029 mm Hg(SRC), determined from a fragment constant method(2), there is a detectable odor; therefore, jasmone may volatilize from dry soil. Jasmone is bicyclic terpene and screening test results of other bicyclic terpenes indicate the compounds are generally biodegradable, but not readily biodegradable(3).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 295(SRC), determined from a structure estimation method(2), indicates that jasmone is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 2.2X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.3 and 21 days, respectively(SRC). According to a classification scheme(4), an estimated BCF of about 100(SRC), from an estimated log Kow of 3.55(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Jasmone is bicyclic terpene and screening test results of other bicyclic terpenes indicate the compounds are generally biodegradable, but not readily biodegradable(5). Jasmone is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). Jasmone is an olefin and olefins in surface waters exposed to sunlight react with photo-oxidants (such as hydroxyl radicals, peroxy radicals and singlet oxygen) with a half-life on the order of 25 days(6).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), jasmone, which has an estimated vapor pressure of 0.029 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase jasmone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.4 hours(SRC), calculated from its rate constant of 1.6X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Vapor-phase jasmone is degraded in the atmosphere by reaction with ozone; the half-life for this reaction in air is estimated to be 0.5 hours(SRC), calculated from its rate constant of 6.1X10-16 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Vapor-phase jasmone is also degraded in the atmosphere by reaction with nitrate radicals; the half-life for this reaction in air is estimated to be 0.8 hours(SRC), calculated from a rate constant of 1.0X10-12 cu cm/molecule-sec at 24 °C(SRC) for analogous olefins(3). Jasmone contains chromophores that absorb at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight.

IDENTIFICATION AND USE: Jasmone is a pale yellow, viscous liquid (oil). It is used in perfumery in fine jasmin bases and floral compositions. HUMAN EXPOSURE AND TOXICITY: Jasmone did not induce dermal sensitization in human volunteers. ANIMAL STUDIES: In an acute dermal toxicity study in 10 rabbits were give 5 g/kg cis-jasmone and observed for 14 days. Severe redness was seen in nine animals and moderate edema was observed in all animals. Eschar was found in two rabbits. Jasmone was not irritating or sensitizing in guinea pigs. In a rabbit eye irritation study, the highest dose group showed strong redness, strong secretion and edema, completely resolving by day 6. The remaining doses showed slight to moderate redness and secretion, completely resolving by day 3. Jasmone was not mutagenic in the Ames plate incorporation and pre-incubation assays with and without metabolic activation at concentrations up to 2500 ug/plate. The strains of Salmonella typhimurium used in the assays were TA98, TA100, TA102, TA1535 and TA1537. However, in a cytogenetic assay in Chinese hamster ovary (CHO) cells frequency of sister-chromatid exchanges (SECs) was significantly increased at concentrations of 33.3 uM and at 100 and 300 uM, the highest dose tested.

The head space constituents of living jasmine flowers contains 3% cis-jasmone(1). Flowers of Japanese honeysuckle (Lonicera japonica) were found to contain cis-jasmone concentrations of 80-602 ug/kg(2). Jasmone was identified in the volatile components of kiwi fruit flowers (Actinidia chinensis Planch)(3). cis-Jasmone is found in the essential oils of jasmine (3%), jonquil, and Pittosporam glabratum, in neroli oil, in peppermint (Mentha piperita), and in bergamont, apricot, raspberry, cinnamon, corn mint and spearmint oils, tea, and soybean(4). cis-Jasmone was detected in the essential oil composition of Feronia elephantum Correa (family: Rutaceae)(5).

Jasmone detections in plants(1).[Table#8269]

Using a structure estimation method based on molecular connectivity indices(1), the Koc of jasmone can be estimated to be 295(SRC). According to a classification scheme(2), this estimated Koc value suggests that jasmone is expected to have moderate mobility in soil.

Jasmone is found in the volatile portion of oil from jasmine flowers(1). Jasmone is found in the essential oils of jasmine (3%), jonquil, and Pittosporam glabratum, in neroli oil, in peppermint (Mentha piperita), and in bergamont, apricot, raspberry, cinnamon, corn mint and spearmint oils, tea, and soybean(2).

/HUMAN EXPOSURE STUDIES/ Repeated insult patch tests were conducted to determine if cis-jasmone would induce dermal sensitization in human volunteers. During the induction phase, 0.5 mL of 2% cis-jasmone in dimethyl phthalate was applied onto an occlusive patch and applied to the upper arm of each volunteer for 24 hr. Induction applications were made to the same site on Monday, Wednesday and Friday for a total of 9 applications during a 3-week period. Following a two week rest period, a challenge patch was applied to a site previously unexposed. Patches were applied as in the induction phase and kept in place for 24 hr before removal. Reactions to the challenge were scored at 48, and 72 hr after application. None of the 54 subjects tested experienced any sensitization reactions.

/HUMAN EXPOSURE STUDIES/ In the induction phase of a maximization study, 1 mL of an 8% cis-jasmone in petrolatum (5520 ug/sq cm) was applied under occlusion for 5 alternate-day 48-hr periods to the same site on the forearm of 25 adult male volunteers. The first induction application was preceded by a 24 hr treatment of 5% sodium lauryl sulfate. Following a 10-14 day rest period, a challenge concentration of 8% cis-jasmone in petrolatum was administered topically under occlusion for 48 hr to a different site on the back. The challenge dose was preceded by a 30 min application of 5% sodium lauryl sulfate. Scoring was done upon removal of the patch and 24 hr thereafter. There were no reactions in any of the subjects. In another study using the same protocol, except that a concentration of 2% sodium lauryl sulfate preceded the first induction application and no application of sodium lauryl sulfate preceded the challenge dose, there was no reaction in 21 adult male and female volunteers.

Jasmone's production and use in perfumery for fine jasmine bases and floral compositions(1,2) and in the reconstitution of synthetic essential oils(3) may result in its release to the environment through various waste streams(SRC). Its use as a perfume(1) and potential use to protect plants against insect pests(4,5) will result in its direct release to the environment(SRC).

AEROBIC: Biodegradation data specific to jasmone were not available(SRC, 2015). However, jasmone belongs to the terpene-terpenoid class of compounds(SRC), and results of biodegradation screening tests for a wide variety of terpene compounds indicate that terpene compounds similar to jasmone are biodegradable with degradation classified as inherently to readily biodegradable(1-3).

An estimated BCF of about 100 was calculated in fish for jasmone(SRC), using an estimated log Kow of 3.55(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate, provided the compound is not metabolized by the organism(SRC).

The Henry's Law constant for jasmone is estimated as 2.2X10-5 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that jasmone is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2.3 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 21 days(SRC). Jasmone's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Even though the vapor pressure is low environmentally at standard temperature and pressure, 0.029 mm Hg(SRC), determined from a fragment constant method(2), there is a detectable odor; therefore, jasmone may volatilize from dry soil.

Chemical: 2-Cyclopenten-1-one, 3-methyl-2-(2-pentenyl)-, (Z)-

Regulation (EC) No 1831/2003 (amended)

2-Cyclopenten-1-one, 3-methyl-2-(2Z)-2-penten-1-yl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Cyclopenten-1-one, 3-methyl-2-(2Z)-2-penten-1-yl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 13-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19000

2-Cyclopenten-1-one, 3-methyl-2-(2Z)-2-pentenyl-: Does not have an individual approval but may be used under an appropriate group standard

3-Methyl-2-(2-pentenyl)-2-cyclopenten-1-one is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and b) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.