5-Fluoroorotic acid monohydrate
Grundinformationen
- CAS
220141-70-8- Standard-SMILES
O.O=C(O)c1[nH]c(=O)[nH]c(=O)c1F- InChIKey
LODRRYMGPWQCTR-UHFFFAOYSA-N- Summenformel
- C5H5FN2O5
- Durchschnittliche Molmasse
- 192,1 g/mol
- Monoisotopische Masse
- 192,01824943
Namen und Bezeichner
- Bevorzugter Name
- 5-Fluoroorotic acid monohydrate
- IUPAC
- 5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid;hydrate
- Englischer Name
- 5-Fluoroorotic acid hydrate 98
- Summenformel
- C5H3FN2O4.H2O
- Molmasse
- 192.1
Namen und Synonyme
220141-70-85-Fluoroorotic acid monohydrateRefChem:535986678-852-35-Fluoroorotic acid hydrate5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate207291-81-4MFCD001506585-Fluoroorotic acid, monohydrate5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid;hydrate5-FLUOROOROTIC ACID HYDRATE 985-Fluoroorotic acid (monohydrate)
Weitere Namen anzeigen
5-Fluoroorotic acid hydrate 985-FOA (5-Fluoroorotic acid), Monohydrate5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid5-Fluoroorotic Acid Monohydrate (5-FOA Monohydrate) for molecular biology, 98%
5-Fluoroorotic Acid Monohydrate (Ultra Pure)C5H5FN2O5Fluoroorotic Monohydrate5-FluorooroticacidhydrateSCHEMBL1476055-fluoroortic acid monohydrate5-fluororotic acid monohydrateorb2695562
Datenbank-Bezeichner
- CAS
220141-70-8- PubChem CID
- 16212749
- EC Number
- 678-852-3
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 96,5 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 1
- Schwere Atome
- 13
- Formalladung
- 0
- Komplexität
- 309
Physikochemische Eigenschaften
- Schmelzpunkt
- 278 °C · 278 °C (dec.)(lit.)
- storage temp.
- -20 °C · Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- Aqueous Base (Heated), DMSO (Sparingly, Heated), Methanol (Sparingly), Water (Sl
- Aggregatzustand
- Solid
- Farbe
- Must be White
- Wasserlöslichkeit
- 50 mg · Soluble in water, dimethyl sulfoxide, 50mg in 1ml (1:1 ammonium hydroxide: water) with gentle heating.
- Merck
- 14 · 14,4176
- BRN
- 181933 · 181933
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 5 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Sicherheitsdaten
- wgk
- 3
- hs_code
- 2933599590
- RTECS-Nr.
- UV7800000
- risk_code
- 22-36/37/38
- hazard_code
- Xn
- safety_code
- 26-36
- hazard_class
- IRRITANT
Chemie und Industrie
Anwendungen
Beschreibung5-fluoro Orotic acid (5-FOA) is used to detect URA3 gene expression in yeast molecular genetic constructs. Yeast with an active URA3 gene, which encodes orotine-5''-monophosphate decarboxylase, converts 5-FOA to fluorodeoxyuridine, which is toxic to cells. Resistant strains of yeast that carry a mutation in the URA3 gene grow in the presence of 5-FOA if the media is supplemented with uracil.
Verwenden5-Fluoroorotic Acid, Monohydrate (5-FOA) has become a valuable tool for research in the field of molecular genetics and has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5í-phosphate decarboxylation.
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